POLR2B and MEN1

Number of citations of the paper that reports this interaction (PubMedID 14992727)
257

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		POLR2B	MEN1
Description		RNA polymerase II subunit B	menin 1
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm RNA Polymerase II, Core Complex Membrane	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Lumen Cytosol Nuclear Matrix Cleavage Furrow Protein-containing Complex Histone Methyltransferase Complex
	Molecular Function	RNA Polymerase II Activity DNA Binding Chromatin Binding RNA Binding DNA-directed 5'-3' RNA Polymerase Activity Protein Binding Ribonucleoside Binding Metal Ion Binding	Four-way Junction DNA Binding Y-form DNA Binding Transcription Cis-regulatory Region Binding Chromatin Binding Double-stranded DNA Binding Protein Binding Protein-macromolecule Adaptor Activity Protein N-terminus Binding Phosphoprotein Binding R-SMAD Binding
	Biological Process	Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Mitotic Cell Cycle Negative Regulation Of Protein Phosphorylation Osteoblast Development Type B Pancreatic Cell Differentiation DNA Repair Regulation Of Transcription By RNA Polymerase II Cellular Response To DNA Damage Stimulus Brain Development Negative Regulation Of Cell Population Proliferation Response To UV Response To Gamma Radiation Negative Regulation Of Cell-substrate Adhesion Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Protein Binding Regulation Of Activin Receptor Signaling Pathway Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of JNK Cascade Decidualization Negative Regulation Of Epithelial Cell Proliferation Histone H3-K4 Methylation Negative Regulation Of Telomerase Activity Regulation Of Type B Pancreatic Cell Proliferation Cellular Response To Glucose Stimulus Cellular Response To Peptide Hormone Stimulus Response To Transforming Growth Factor Beta Negative Regulation Of Cell Cycle G1/S Phase Transition
Pathways		Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Viral Messenger RNA Synthesis MicroRNA (miRNA) biogenesis Transcriptional regulation by small RNAs PIWI-interacting RNA (piRNA) biogenesis Activation of anterior HOX genes in hindbrain development during early embryogenesis RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes FGFR2 alternative splicing RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes mRNA Capping mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE Signaling by FGFR2 IIIa TM Estrogen-dependent gene expression Inhibition of DNA recombination at telomere	Formation of the beta-catenin:TCF transactivating complex SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Deactivation of the beta-catenin transactivating complex Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) RHO GTPases activate IQGAPs Post-translational protein phosphorylation
Drugs
Diseases
GWAS		Age-related macular degeneration ( 21909106) Bitter alcoholic beverage consumption ( 31046077) Congenital heart disease (maternal effect) ( 28468790) Coronary artery disease ( 29212778) Height ( 20881960 25429064) Metabolite levels ( 23823483) White blood cell count ( 29403010)	Urate levels ( 21768215)
Interacting Genes		19 interacting genes: BTF3 CALM1 CCNH CDK7 CTDP1 IKBKG ITCH LZTR1 MEN1 NEDD4 OTUD5 POLR2C POLR2D POLR2H POLR2L PTEN SNAR-B2 SUB1 ZSCAN1	32 interacting genes: ASH2L CTNNB1 DAXX DBF4 ESR1 FANCD2 FOXN3 GFAP H3-4 HDAC1 HDAC2 IQGAP1 JUND KMT2A KMT2D MYC MYH9 NFKB1 NFKB2 POLR2B RBBP5 RELA RPA2 SIN3A SMAD1 SMAD3 SMAD5 SNW1 TCF3 TCF7L2 TP53 VIM
Entrez ID		5431	4221
HPRD ID		15943	00564
Ensembl ID		ENSG00000047315	ENSG00000133895
Uniprot IDs		B4DH29 B4DHJ3 C9J2Y9 P30876	A0A024R5D2 A0A024R5E3 A0A5F9ZHS3 O00255 Q9GZQ5
PDB IDs		5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 6DRD 6O9L	3U84 3U85 3U86 3U88 4GPQ 4GQ3 4GQ4 4GQ6 4I80 4OG3 4OG4 4OG5 4OG6 4OG7 4OG8 4X5Y 4X5Z 5DB0 5DB1 5DB2 5DB3 5DD9 5DDA 5DDB 5DDC 5DDD 5DDE 5DDF 6B41 6BXH 6BXY 6BY8 6E1A 6O5I 6OPJ 6PKC 6S2K 6WNH
Enriched GO Terms of Interacting Partners?
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