POLE3 and POLE4

Number of citations of the paper that reports this interaction (PubMedID 10801849)
28

Data Source:
HPRD (in vitro)

		POLE3	POLE4
Description		DNA polymerase epsilon 3, accessory subunit	DNA polymerase epsilon 4, accessory subunit
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Epsilon DNA Polymerase Complex CHRAC	Nucleus Nucleoplasm Epsilon DNA Polymerase Complex
	Molecular Function	DNA-directed DNA Polymerase Activity Protein Binding Chromatin DNA Binding Protein Heterodimerization Activity	DNA Binding DNA-directed DNA Polymerase Activity Protein Binding Protein Heterodimerization Activity
	Biological Process	DNA Replication Leading Strand Elongation Cellular Response To DNA Damage Stimulus Heterochromatin Assembly Nucleosome Mobilization Histone H3 Acetylation DNA Biosynthetic Process	DNA Biosynthetic Process
Pathways		Recognition of DNA damage by PCNA-containing replication complex PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER DNA replication initiation Activation of the pre-replicative complex	Recognition of DNA damage by PCNA-containing replication complex PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER DNA replication initiation Activation of the pre-replicative complex
Drugs		Cladribine	Cladribine
Diseases
GWAS			Venous thromboembolism ( 33592630)
Interacting Genes		14 interacting genes: ALAD APP ASTN2 BAZ1A CHRAC1 CST3 DR1 DRAP1 EIF4G2 GSN POLE4 SMARCA5 TNC TRIM32	11 interacting genes: B4GALT4 EVA1A HSPA13 NFYB POLE POLE2 POLE3 PRKAR1B REG3G SGO1 UBE3A
Entrez ID		54107	56655
HPRD ID		06274	16238
Ensembl ID		ENSG00000148229	ENSG00000115350
Uniprot IDs		A0A024R829 Q9NRF9	Q9NR33
PDB IDs
Enriched GO Terms of Interacting Partners?
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