DUOX1 and TPO

Number of citations of the paper that reports this interaction (PubMedID 15561711)
22

Data Source:
HPRD (in vivo)

		DUOX1	TPO
Description		dual oxidase 1	thyroid peroxidase
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Cell Surface Apical Plasma Membrane Cell Leading Edge NADPH Oxidase Complex	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Cell Surface
	Molecular Function	Peroxidase Activity Calcium Ion Binding Protein Binding NAD(P)H Oxidase H2O2-forming Activity Superoxide-generating NAD(P)H Oxidase Activity Heme Binding NADP Binding NADH Oxidase H202-forming Activity NADPH Oxidase H202-forming Activity	Iodide Peroxidase Activity Peroxidase Activity Calcium Ion Binding Heme Binding
	Biological Process	Thyroid Hormone Generation Defense Response Response To Oxidative Stress Cytokine-mediated Signaling Pathway Cuticle Development Hormone Biosynthetic Process Superoxide Anion Generation Hydrogen Peroxide Catabolic Process Hydrogen Peroxide Biosynthetic Process Response To CAMP Positive Regulation Of Wound Healing Cellular Oxidant Detoxification Positive Regulation Of Cell Motility	Thyroid Hormone Generation Response To Oxidative Stress Embryonic Hemopoiesis Hormone Biosynthetic Process Hydrogen Peroxide Catabolic Process Cellular Oxidant Detoxification
Pathways		Thyroxine biosynthesis	Thyroxine biosynthesis
Drugs			Carbimazole Dextrothyroxine Propylthiouracil Methimazole Triclosan Resorcinol 2-mercaptobenzothiazole
Diseases
GWAS			Autoimmune thyroid disease ( 32581359) Hypothyroidism ( 30367059 27182965) Medication use (thyroid preparations) ( 31015401) Placebo response in major depressive disorder (% change in symptom score) ( 28696415) Thrombin-activatable fibrinolysis inhibitor levels ( 29378355) Thyroid peroxidase antibody levels ( 24586183) Thyroid peroxidase antibody positivity ( 24722205 24586183) Thyroid stimulating hormone levels ( 32769997)
Interacting Genes		2 interacting genes: TPO TXNDC11	3 interacting genes: DUOX1 DUSP6 TXNDC11
Entrez ID		53905	7173
HPRD ID		08421	06000
Ensembl ID		ENSG00000137857	ENSG00000115705
Uniprot IDs		Q9NRD9	P07202 Q502Y3 Q6P534
PDB IDs		7D3E 7D3F
Enriched GO Terms of Interacting Partners?
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