ATP7A and ATOX1

Number of citations of the paper that reports this interaction (PubMedID 10557326)
69

Data Source:
BioGRID (pull down, two hybrid)
HPRD (in vivo)

		ATP7A	ATOX1
Description		ATPase copper transporting alpha	antioxidant 1 copper chaperone
Image
GO Annotations	Cellular Component	Nucleus Late Endosome Endoplasmic Reticulum Golgi Apparatus Trans-Golgi Network Cytosol Plasma Membrane Microvillus Postsynaptic Density Membrane Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane Trans-Golgi Network Transport Vesicle Secretory Granule Axon Dendrite Phagocytic Vesicle Membrane Cell Leading Edge Brush Border Membrane Early Endosome Membrane Trans-Golgi Network Membrane Melanosome Membrane Neuron Projection Neuronal Cell Body Perikaryon Membrane Raft Perinuclear Region Of Cytoplasm	Cytosol
	Molecular Function	Copper Ion Transmembrane Transporter Activity Copper Ion Binding Protein Binding ATP Binding Superoxide Dismutase Copper Chaperone Activity ATP Hydrolysis Activity Small GTPase Binding Copper-dependent Protein Binding P-type Divalent Copper Transporter Activity Chaperone Binding P-type Monovalent Copper Transporter Activity Cuprous Ion Binding	Copper Ion Binding Protein Binding Metallochaperone Activity Copper Chaperone Activity Copper-dependent Protein Binding ATPase Binding Cuprous Ion Binding
	Biological Process	Blood Vessel Development In Utero Embryonic Development Liver Development Blood Vessel Remodeling Regulation Of Oxidative Phosphorylation Tryptophan Metabolic Process Catecholamine Metabolic Process Copper Ion Transport Cellular Copper Ion Homeostasis Mitochondrion Organization Female Pregnancy Lactation Locomotory Behavior Response To Iron(III) Ion Response To Manganese Ion Response To Zinc Ion Detoxification Of Copper Ion Regulation Of Gene Expression Positive Regulation Of Lamellipodium Assembly Copper Ion Import Peptidyl-lysine Modification Removal Of Superoxide Radicals Cerebellar Purkinje Cell Differentiation Pyramidal Neuron Development Central Nervous System Neuron Development Extracellular Matrix Organization Collagen Fibril Organization Hair Follicle Morphogenesis Positive Regulation Of Tyrosinase Activity Negative Regulation Of Iron Ion Transmembrane Transport Cellular Response To Platelet-derived Growth Factor Stimulus T-helper Cell Differentiation Epinephrine Metabolic Process Norepinephrine Metabolic Process Dopamine Metabolic Process Serotonin Metabolic Process Positive Regulation Of Catalytic Activity Pigmentation Skin Development Positive Regulation Of Cell Size Positive Regulation Of Melanin Biosynthetic Process Elastic Fiber Assembly Lung Alveolus Development Neuron Projection Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Cartilage Development Positive Regulation Of Oxidoreductase Activity Elastin Biosynthetic Process Copper Ion Homeostasis Copper Ion Export Cellular Response To Amino Acid Stimulus Cellular Response To Antibiotic Cellular Response To Cadmium Ion Cellular Response To Cobalt Ion Cellular Response To Copper Ion Cellular Response To Iron Ion Cellular Response To Lead Ion Cellular Response To Hypoxia Positive Regulation Of Response To Wounding Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Regulation Of Cytochrome-c Oxidase Activity	Copper Ion Transport Negative Regulation Of Apoptotic Process Copper Ion Export
Pathways		Detoxification of Reactive Oxygen Species Ion influx/efflux at host-pathogen interface Ion transport by P-type ATPases	Detoxification of Reactive Oxygen Species Ion influx/efflux at host-pathogen interface
Drugs			Cisplatin Sucrose Benzamidine
Diseases
GWAS		Height ( 31562340)	Creatinine levels ( 29403010) Glomerular filtration rate ( 29403010) Red cell distribution width ( 32888494) Systolic blood pressure change trajectory ( 27980656)
Interacting Genes		3 interacting genes: ATOX1 CP PDZD11	9 interacting genes: ATP7A ATP7B CFAP410 COMP FAM118A FKBP4 GGPS1 NECAB1 TRAF4
Entrez ID		538	475
HPRD ID		02054	03779
Ensembl ID		ENSG00000165240	ENSG00000177556
Uniprot IDs		B4DRW0 Q04656 Q762B6	O00244
PDB IDs		1AW0 1KVI 1KVJ 1Q8L 1S6O 1S6U 1Y3J 1Y3K 1YJR 1YJT 1YJU 1YJV 2AW0 2G9O 2GA7 2K1R 2KIJ 2KMV 2KMX 3CJK 5T7L	1FE0 1FE4 1FEE 1TL4 1TL5 2K1R 2LQ9 3CJK 3IWL 3IWX 4QOT 4YDX 4YEA 5F0W 5T7L
Enriched GO Terms of Interacting Partners?
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