PML and USP11

Number of citations of the paper that reports this interaction (PubMedID 24487962)
37

Data Source:
BioGRID (enzymatic study)

		PML	USP11
Description		PML nuclear body scaffold	ubiquitin specific peptidase 11
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin Heterochromatin Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Nuclear Matrix PML Body Early Endosome Membrane Extrinsic Component Of Endoplasmic Reticulum Membrane	Nucleus Nucleoplasm Chromosome Cytosol
	Molecular Function	DNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding SUMO Transferase Activity Ubiquitin Protein Ligase Binding SUMO Binding Protein Homodimerization Activity SMAD Binding Sumo-dependent Protein Binding	Transcription Corepressor Binding Cysteine-type Endopeptidase Activity Thiol-dependent Deubiquitinase Protein Binding
	Biological Process	Response To Hypoxia Regulation Of Protein Phosphorylation Regulation Of Transcription, DNA-templated Protein Import Into Nucleus Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Transforming Growth Factor Beta Receptor Signaling Pathway Common-partner SMAD Protein Phosphorylation Negative Regulation Of Cell Population Proliferation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Response To UV Response To Gamma Radiation Regulation Of Calcium Ion Transport Into Cytosol Fibroblast Migration Negative Regulation Of Angiogenesis Protein Ubiquitination Protein Sumoylation Myeloid Cell Differentiation Regulation Of Cell Adhesion Negative Regulation Of Cell Growth PML Body Organization Positive Regulation Of Telomere Maintenance Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Interleukin-1 Beta Production Circadian Regulation Of Gene Expression Response To Cytokine Regulation Of Circadian Rhythm Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Entrainment Of Circadian Clock By Photoperiod Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Cell Fate Commitment Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Fibroblast Proliferation Retinoic Acid Receptor Signaling Pathway Maintenance Of Protein Location In Nucleus Defense Response To Virus Branching Involved In Mammary Gland Duct Morphogenesis Protein-containing Complex Assembly Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Cellular Response To Interleukin-4 Cellular Senescence Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Viral Release From Host Cell Cellular Response To Leukemia Inhibitory Factor Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Double-strand Break Repair Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Ubiquitin-dependent Protein Catabolic Process Protein Deubiquitination
Pathways		SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Regulation of TP53 Activity through Acetylation Interferon gamma signaling Regulation of RUNX1 Expression and Activity Regulation of PTEN localization HCMV Early Events	Association of TriC/CCT with target proteins during biosynthesis Ub-specific processing proteases
Drugs		Arsenic trioxide
Diseases
GWAS		Accelerometer-based physical activity measurement (fraction of time with accelerations >425 milli-gravities) ( 29899525) Appendicular lean mass ( 33097823) Birth weight ( 31043758) Height ( 28552196 20881960 25282103) Hip circumference adjusted for BMI ( 34021172) Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566) Insomnia symptoms (never/rarely vs. usually) ( 30804566) Myopia (pathological) ( 23049088) Paget's disease ( 21623375) Physical activity (overall physical activity time) ( 30531941) White blood cell count ( 32888494)
Interacting Genes		112 interacting genes: ADH1B ANKRD2 ARID3A ARNT ATF2 ATXN1 AURKA AXIN1 BANP BCL2 BCL6 CASP8AP2 CCNT1 CDK1 CDK2 CDK6 CHFR CREBBP CSNK2A1 DAXX EGFR EIF4E ELF4 EP300 ERCC6 FOS FXR1 GATA1 GATA2 HDAC1 HDAC2 HDAC3 HHEX HIPK2 HTT JUN KAT5 KAT6A KLHL20 MAD1L1 MAPK11 MAPK14 MDM2 MED7 MXD1 MYB MYC NACC1 NCOA2 NCOR1 NCOR2 NFKB1 NR3C1 NR4A1 PAWR PAXIP1 PCBD2 PIAS1 PIAS2 PIN1 PLAGL1 PLSCR1 POLR2E PPARG PSMA3 RARA RB1 RBX1 RELA RNF111 RNF125 RPL11 RXRA SENP1 SENP2 SH3GL1 SIAH2 SIN3A SIRT1 SKI SLC27A2 SMAD3 SP1 SP100 SRF STAT3 SUMO1 SUMO2 SUMO3 SUV39H1 SYNE2 TDG TERF2IP TGFBR1 TGFBR2 TGIF1 THRA TOPBP1 TP53 TP63 TP73 TRIB3 TRIM24 TRIM27 TRIM69 UBE2I UBE2U UBE3A USP11 ZBTB16 ZFYVE9 ZNF451	22 interacting genes: BMI1 BRCA2 CBX8 CDKN1A DECR2 EIF4B LIMS1 LLGL1 MBD3 MTA2 NONO PCGF2 PML RANBP9 RELB RNF2 RPS6KB1 SETDB1 SUMO2 TBL3 TP53 UBC
Entrez ID		5371	8237
HPRD ID		00023	02081
Ensembl ID		ENSG00000140464	ENSG00000102226
Uniprot IDs		P29590	B4DGK3 P51784
PDB IDs		1BOR 2MVW 2MWX 4WJN 4WJO 5YUF 6IMQ 6UYO 6UYP 6UYQ 6UYR 6UYS 6UYT 6UYU 6UYV	4MEL 5OK6
Enriched GO Terms of Interacting Partners?
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