PLSCR1 and CTSZ

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		PLSCR1	CTSZ
Description		phospholipid scramblase 1	cathepsin Z
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Integral Component Of Plasma Membrane Membrane Membrane Raft Perinuclear Region Of Cytoplasm Collagen-containing Extracellular Matrix Extracellular Exosome	Extracellular Region Extracellular Space Lysosome Endoplasmic Reticulum Endoplasmic Reticulum Lumen Plasma Membrane Cell Surface COPII-coated ER To Golgi Transport Vesicle Growth Cone Cytoplasmic Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Specific Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Cell Cortex Region Ficolin-1-rich Granule Lumen
	Molecular Function	Magnesium Ion Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Virus Receptor Activity DNA Binding Nuclease Activity Epidermal Growth Factor Receptor Binding Calcium Ion Binding Protein Binding Zinc Ion Binding SH3 Domain Binding Phospholipid Scramblase Activity Enzyme Binding Lead Ion Binding CD4 Receptor Binding Mercury Ion Binding	Carboxypeptidase Activity Cysteine-type Endopeptidase Activity Protein Binding Cysteine-type Peptidase Activity
	Biological Process	Phosphatidylserine Biosynthetic Process Apoptotic Process Acute-phase Response Response To Lead Ion Positive Regulation Of Gene Expression Plasma Membrane Phospholipid Scrambling Platelet Activation Regulation Of Mast Cell Activation Response To Interferon-beta Negative Regulation Of Viral Genome Replication Positive Regulation Of Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Viral Entry Into Host Cell Negative Regulation Of Phagocytosis Defense Response To Virus Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Phosphatidylserine Exposure On Apoptotic Cell Surface Nucleic Acid Phosphodiester Bond Hydrolysis Positive Regulation Of Chromosome Separation Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity	Angiotensin Maturation Proteolysis Negative Regulation Of Plasminogen Activation Negative Regulation Of Neuron Projection Development Negative Regulation Of Protein Binding Positive Regulation Of Neuron Apoptotic Process Proteolysis Involved In Cellular Protein Catabolic Process Epithelial Tube Branching Involved In Lung Morphogenesis Regulation Of Neuron Death Positive Regulation Of Neural Precursor Cell Proliferation
Pathways			Metabolism of Angiotensinogen to Angiotensins COPII-mediated vesicle transport Lysosome Vesicle Biogenesis Cargo concentration in the ER Neutrophil degranulation
Drugs
Diseases
GWAS		Gut microbiota (beta diversity) ( 27723756)	Blood protein levels ( 30072576 29875488) Hematocrit ( 32888494) Inflammatory bowel disease ( 23128233) Lymphocyte counts ( 32888494) Mean platelet volume ( 22139419 24026423 32888494 27863252) Platelet count ( 32888494) Platelet distribution width ( 32888494 27863252)
Interacting Genes		130 interacting genes: ABL1 ADAMTSL4 ADCY7 ANXA11 APP ARNT2 ATG12 ATN1 BACE1 BCL6B C10orf62 CATSPER1 CCDC33 CCER1 CDC42EP1 CHRD CNTFR CPSF6 CRK CRKL CRY1 CTBP1-DT CTSZ DAZAP2 DDIAS DEF6 DEPP1 DHRS1 DLK2 DMRT3 DOCK2 DTX2 EFEMP2 EGFR ENKD1 EP300 ESR2 EWSR1 EXD3 FAM107A FBLN1 FBXL18 FGFR2 FRAT1 FRS3 GDPD5 GLRX3 GNAI2 GPRIN2 HEY2 HOXA1 HOXA9 HOXB6 HRG ILF3 INTS11 IP6K2 IQCN KIF1A KRTAP10-11 KRTAP10-3 KRTAP10-9 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP5-6 KRTAP9-2 LASP1 LCE2D LCE3C LCE4A LGALS9C LINC00663 LINC01547 LONRF1 MAPK6 MED15 MGAT5B MVP NECAP2 NEU4 NOC4L NPDC1 NR0B2 NTN4 OGDH P2RY6 PCED1A PGLS PHLDA1 PITX1 PKD2 PLSCR3 PLSCR4 PML PRKCD PRR13 RAMAC RASD1 RBL1 RERE RGS3 RXRB SCNM1 SF1 SHC1 SLC25A6 SLC35A2 SLPI SMARCC1 SMCP SPATA8 SPG7 SPRY2 SRC STK16 TFG TRAF4 TRIM42 VASP VPS37C VSIR YIPF3 ZBTB16 ZNF417 ZNF581 ZNF587 ZNF638 ZNF688 ZNF764	21 interacting genes: BACH2 BANP CYSRT1 FHL5 HSF2BP KRT35 KRT40 KRTAP1-1 KRTAP10-1 KRTAP10-10 KRTAP2-3 KRTAP2-4 KRTAP3-3 KRTAP5-9 KRTAP6-3 MID2 MTUS2 NBPF19 NOTCH2NLA PLSCR1 TNS2
Entrez ID		5359	1522
HPRD ID		08855	04410
Ensembl ID		ENSG00000188313	ENSG00000101160
Uniprot IDs		O15162	Q9UBR2
PDB IDs		1Y2A	1DEU 1EF7
Enriched GO Terms of Interacting Partners?
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