SERPINF2 and DEFA1

Number of citations of the paper that reports this interaction (PubMedID 7873202)
33

Data Source:
HPRD (in vitro)

		SERPINF2	DEFA1
Description		serpin family F member 2	defensin alpha 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Fibrinogen Complex Extracellular Space Cell Surface Platelet Alpha Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle	Extracellular Region Extracellular Space Golgi Lumen Azurophil Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Protease Binding Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding Protein Homodimerization Activity	Protein Binding
	Biological Process	Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Acute-phase Response Negative Regulation Of Plasminogen Activation Negative Regulation Of Endopeptidase Activity Collagen Fibril Organization Positive Regulation Of Collagen Biosynthetic Process Fibrinolysis Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Blood Vessel Morphogenesis Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Fibrinolysis Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin	Innate Immune Response In Mucosa Chemotaxis Immune Response T Cell Chemotaxis Antibacterial Humoral Response Intracellular Estrogen Receptor Signaling Pathway Killing Of Cells Of Other Organism Defense Response To Protozoan Pore Formation In Membrane Of Other Organism During Symbiotic Interaction Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Defense Response To Fungus Defense Response To Virus Membrane Disruption In Other Organism Killing By Host Of Symbiont Cells Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cellular Response To Lipopolysaccharide
Pathways		Platelet degranulation Dissolution of Fibrin Clot	Defensins Alpha-defensins Neutrophil degranulation
Drugs		Ocriplasmin Copper
Diseases
GWAS		Blood protein levels ( 29875488) Calcium levels ( 24068962 20705733) Hodgkin's lymphoma ( 34216518) Serum albumin level ( 23022100 29403010) Urate levels ( 31578528)	Basophil percentage of white cells ( 32888494) Blood protein levels ( 30072576) Chromium levels ( 26025379) Dental caries (decayed and filled deciduous teeth) ( 31533690) Endometriosis ( 28333195) Periodontitis (PAL4Q3) ( 24024966)
Interacting Genes		18 interacting genes: BCAP31 CFD CTRB1 DEFA1 ELANE F11 F13A1 FGA KLK13 KLK2 KLK6 MYH10 PLAU PLG PRSS1 SERPINB12 SSR1 TGM2	6 interacting genes: C1QB DEFA3 GSK3B PFDN1 SERPINF2 UBQLN2
Entrez ID		5345	1667
HPRD ID		02029	00499
Ensembl ID		ENSG00000167711	ENSG00000206047
Uniprot IDs		P08697	P59665
PDB IDs			2KHT 2PM1 3GNY 3H6C 3HJ2 3HJD 3LO1 3LO2 3LO4 3LO6 3LO9 3LOE 3LVX 4DU0 4LB1 4LB7 4LBB 4LBF
Enriched GO Terms of Interacting Partners?
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