PLD2 and AQP3

Number of citations of the paper that reports this interaction (PubMedID 14675200)
35

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo, in vitro)

		PLD2	AQP3
Description		phospholipase D2	aquaporin 3 (Gill blood group)
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Plasma Membrane Presynapse	Nucleoplasm Cytoplasm Plasma Membrane Cell-cell Junction Integral Component Of Membrane Basolateral Plasma Membrane
	Molecular Function	Phospholipase D Activity Protein Binding Phosphatidylinositol Binding N-acylphosphatidylethanolamine-specific Phospholipase D Activity	Protein Binding Urea Transmembrane Transporter Activity Water Channel Activity Glycerol Channel Activity Identical Protein Binding
	Biological Process	Phosphatidic Acid Biosynthetic Process Cytoskeleton Organization Small GTPase Mediated Signal Transduction Lipid Catabolic Process Synaptic Vesicle Recycling Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Inositol Lipid-mediated Signaling Cell Motility	Positive Regulation Of Immune System Process Renal Water Homeostasis Water Transport Glycerol Transport Response To Retinoic Acid Response To Vitamin D Odontogenesis Regulation Of Keratinocyte Differentiation Response To Calcium Ion Renal Water Absorption Cellular Response To Hypoxia Urea Transmembrane Transport Cellular Response To Oxygen-glucose Deprivation
Pathways		Synthesis of PG Synthesis of PA Role of phospholipids in phagocytosis RAC1 GTPase cycle RAC2 GTPase cycle	Vasopressin regulates renal water homeostasis via Aquaporins Passive transport by Aquaporins
Drugs		Choline Choline salicylate	Sennosides
Diseases
GWAS		Sphingolipid levels ( 22359512) Systemic lupus erythematosus ( 26502338)	Lung adenocarcinoma ( 28604730 31326317) Neuroblastoma or malignant cutaneous melanoma ( 31605138)
Interacting Genes		30 interacting genes: ACTB ACTN1 ALDOA ALDOC AMPH AQP3 ARF1 BIN1 CAV1 CSK DPYSL2 EGFR FYN GAPDH GM2A HIF1A LCK MTDH MTOR OPRM1 PEA15 PIP5K1A PLCG1 PRKCA PRKCD RPTOR SRC STXBP1 TIMM10B VHL	28 interacting genes: C14orf180 CD79A ERG28 ERGIC3 EVI2B FAM209A GIMAP5 GPR152 GPX8 HIBADH LEUTX LMNA MFF MGST3 MRM1 MUC1 OLFM4 PLD2 PLP2 SAR1A SGPL1 SSMEM1 STX1A TMEM107 TMEM42 TMEM86A TNF VASN
Entrez ID		5338	360
HPRD ID		03857	08970
Ensembl ID		ENSG00000129219	ENSG00000165272
Uniprot IDs		O14939	A0A2R8Y2R4 Q92482
PDB IDs		6OHM 6OHO 6OHP 6OHQ 6OHS
Enriched GO Terms of Interacting Partners?
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