PLCG2 and NPM1

Number of citations of the paper that reports this interaction (PubMedID 9819383)
65

Data Source:
HPRD (in vivo)

		PLCG2	NPM1
Description		phospholipase C gamma 2	nucleophosmin 1
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Ruffle Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome Intracellular Vesicle	Granular Component Nucleus Nucleoplasm Nucleolus Cytoplasm Centrosome Cytosol Focal Adhesion Large Ribosomal Subunit Small Ribosomal Subunit Membrane Nuclear Speck Spindle Pole Centrosome Protein-containing Complex Protein-DNA Complex Ribonucleoprotein Complex
	Molecular Function	Phosphotyrosine Residue Binding Phosphatidylinositol Phospholipase C Activity Phospholipase C Activity Protein Binding Protein Kinase Binding Scaffold Protein Binding Phosphorylation-dependent Protein Binding Protein Tyrosine Kinase Binding	Core Promoter Sequence-specific DNA Binding Chromatin Binding Transcription Coactivator Activity RNA Binding Protein Kinase Inhibitor Activity Protein Binding RRNA Binding Protein Kinase Binding Tat Protein Binding Histone Binding Protein Homodimerization Activity Ribosomal Large Subunit Binding Ribosomal Small Subunit Binding Protein N-terminus Binding NF-kappaB Binding Unfolded Protein Binding DNA-binding Transcription Factor Binding
	Biological Process	Cell Activation Response To Yeast Positive Regulation Of Receptor Internalization Stimulatory C-type Lectin Receptor Signaling Pathway Toll-like Receptor Signaling Pathway Macrophage Activation Involved In Immune Response Follicular B Cell Differentiation Positive Regulation Of Dendritic Cell Cytokine Production Phosphatidylinositol Biosynthetic Process Phospholipid Catabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Epithelial Cell Migration Wnt Signaling Pathway Regulation Of Lipid Metabolic Process Calcium-mediated Signaling Platelet Activation B Cell Differentiation Lipopolysaccharide-mediated Signaling Pathway Activation Of Store-operated Calcium Channel Activity Positive Regulation Of Type I Interferon Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-23 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Inositol Trisphosphate Biosynthetic Process Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Negative Regulation Of Programmed Cell Death Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAPK Cascade Response To Axon Injury Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Calcium-mediated Signaling T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Phagocytosis, Engulfment Positive Regulation Of Macrophage Cytokine Production Antifungal Innate Immune Response Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Calcium Ion Cellular Response To Lipid Positive Regulation Of Neuroinflammatory Response Positive Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of I-kappaB Phosphorylation Cellular Response To Lectin	Ribosomal Large Subunit Export From Nucleus Ribosomal Small Subunit Export From Nucleus Regulation Of Cell Growth DNA Repair Nucleosome Assembly Chromatin Remodeling RRNA Export From Nucleus Cell Volume Homeostasis Intracellular Protein Transport Nucleocytoplasmic Transport Centrosome Cycle Signal Transduction Cell Aging Protein Localization Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Regulation Of Centrosome Duplication Positive Regulation Of Centrosome Duplication Negative Regulation Of Centrosome Duplication Positive Regulation Of Protein Ubiquitination Regulation Of Endodeoxyribonuclease Activity Cellular Response To UV Ribosome Assembly Ribosomal Large Subunit Biogenesis Ribosomal Small Subunit Biogenesis Negative Regulation Of Apoptotic Process Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Positive Regulation Of Translation Positive Regulation Of Protein Kinase Activity Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Centriole Replication Negative Regulation Of MRNA Splicing, Via Spliceosome Protein Stabilization Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Endoribonuclease Activity Regulation Of EIF2 Alpha Phosphorylation By DsRNA Regulation Of MRNA Stability Involved In Cellular Response To UV Positive Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Protein Localization To Nucleolus
Pathways		GPVI-mediated activation cascade Toll Like Receptor 4 (TLR4) Cascade Synthesis of IP3 and IP4 in the cytosol Generation of second messenger molecules Role of phospholipids in phagocytosis DAP12 signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization CLEC7A (Dectin-1) signaling CLEC7A (Dectin-1) signaling Dectin-2 family Dectin-2 family Erythropoietin activates Phospholipase C gamma (PLCG) FCGR3A-mediated IL10 synthesis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	Nuclear import of Rev protein Nuclear import of Rev protein SUMOylation of transcription cofactors Deposition of new CENPA-containing nucleosomes at the centromere TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation ALK mutants bind TKIs Signaling by ALK fusions and activated point mutants Nuclear events stimulated by ALK signaling in cancer
Drugs			Artenimol
Diseases
GWAS		Alzheimer's disease ( 34099642) Alzheimer's disease (late onset) ( 28714976) Blood protein levels ( 30072576) Breast cancer (menopausal hormone therapy interaction) ( 24080446) Ceramide levels (C24:0) ( 32489964) Chronic widespread musculoskeletal pain ( 33331911) Coronary artery disease ( 29212778 33020668) Dental caries (decayed, missing and filled teeth) ( 31533690) Height ( 28552196) Inflammatory bowel disease ( 28067908) Mean platelet volume ( 32888494 27863252) Metabolite levels ( 23823483) Myocardial infarction ( 33532862) Platelet count ( 32888494) Platelet distribution width ( 32888494 27863252) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Serum metabolite levels ( 33031748) Takayasu arteritis ( 33308445) Ulcerative colitis ( 28067908) Upper eyelid morphology ( 29921221) Venous thromboembolism ( 31420334 31676865) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Brain morphology (MOSTest) ( 32665545) Height ( 28552196) Multisite chronic pain ( 33830993) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		57 interacting genes: AR ASB9 BLK BLNK BTK CBLB CD19 DAPP1 EGFR ELK1 EPOR EPYC ERBB2 ERBB3 ERBB4 ESD FCER1G FLT1 FYN GAB1 GAB2 GABPB2 HCK HSPD1 IRF8 IRS1 ISL1 ITK JAK1 JAK2 KCTD17 KDR KHDRBS1 KIT LAT LAT2 LCK LCP2 LHX8 LIME1 LYN MET NPM1 PRKD1 PTPN6 PTTG1 RALBP1 RTL10 SETD9 SH3BP2 SHC1 SYK TEC TP53 TWIST2 ZKSCAN7 ZNF512B	65 interacting genes: ABCC1 ACY1 ALK APP ARF1 CACYBP CCR1 CD24 CDK1 CDK2 CDKN2A CDT1 CENPW CLK1 COX8A CSNK2A1 DUX4 EIF2AK2 ELF4 EP300 ERG ESR1 FBXW7 GADD45A GNAI2 GNL3 GRB2 GZMM H2AC20 H2BC21 H3-4 HAND2 HMGA1 HMGA2 HOXA7 IRF1 IRS1 LINC01554 MDM2 NCL NOP2 NPM2 OGT PADI4 PARP1 PLCG1 PLCG2 PLK1 PSMC4 RELA RPGR SENP3 SHC1 SIL1 SP1 SREK1 SUMO2 TCERG1 TFAP2A TP53 TRIM28 UBC UQCRH XPO1 YY1
Entrez ID		5336	4869
HPRD ID		02570	01246
Ensembl ID		ENSG00000197943	ENSG00000181163
Uniprot IDs		P16885	A0A0S2Z491 A0A0S2Z4G7 A0A140VJQ2 P06748
PDB IDs		2K2J 2W2W 2W2X	2LLH 2P1B 2VXD 5EHD
Enriched GO Terms of Interacting Partners?
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