PLCD1 and TGM2

Number of citations of the paper that reports this interaction (PubMedID 10518533)
24

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		PLCD1	TGM2
Description		phospholipase C delta 1	transglutaminase 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Extracellular Exosome	Chromatin Nucleus Mitochondrion Endoplasmic Reticulum Cytosol Plasma Membrane Focal Adhesion Extracellular Matrix Intrinsic Component Of Plasma Membrane Perinuclear Region Of Cytoplasm Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Phosphatidylinositol Phospholipase C Activity Calcium Ion Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding GTPase Activating Protein Binding	Protein-glutamine Gamma-glutamyltransferase Activity Calcium Ion Binding Protein Binding GTP Binding Peptidase Activity Protein Domain Specific Binding Identical Protein Binding Protein-glutamine Glutaminase Activity Histone Serotonyltransferase Activity Histone Dopaminyltransferase Activity Peptide Noradrenalinyltransferase Activity Peptide Histaminyltransferase Activity
	Biological Process	Phospholipid Metabolic Process Lipid Catabolic Process Phosphatidylinositol Metabolic Process Phosphatidylinositol-mediated Signaling	Blood Vessel Remodeling Proteolysis Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Peptide Cross-linking Isopeptide Cross-linking Via N6-(L-isoglutamyl)-L-lysine Protein Deamination Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Apoptotic Cell Clearance Positive Regulation Of GTPase Activity Positive Regulation Of Cell Adhesion Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Inflammatory Response Positive Regulation Of Neurogenesis Positive Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Positive Regulation Of Mitochondrial Calcium Ion Concentration Bone Development Branching Involved In Salivary Gland Morphogenesis Salivary Gland Cavitation Cellular Response To Cocaine Cellular Response To Dopamine Cellular Response To Serotonin Regulation Of Apoptotic Cell Clearance
Pathways		Synthesis of IP3 and IP4 in the cytosol
Drugs		1D-myo-inositol 1,4,5-trisphosphate Inositol 2,4,5-trisphosphate	Guanosine-5'-Diphosphate Hexylresorcinol
Diseases
GWAS
Interacting Genes		11 interacting genes: APP CALM1 GAP43 HGS KPNB1 NTAQ1 PAXIP1 RALA RALB TGM2 USP54	60 interacting genes: A2M ABCA1 ACTB ADAR ALDOA ANKRD28 ANXA1 APP ARNT ATF4 BNIP3 C3 CASP3 CBL CERT1 CSNK2A2 EIF5A FN1 FNTA GCGR GRN GSTP1 H2BC21 H2BC8 HNRNPF HNRNPUL1 HP HSPA1A HSPA1B HSPA8 HTT ITGB1 ITGB3 KPNA3 KPNA4 LACRT LTBP1 MAP3K12 MMP14 PAK1 PINK1 PLCD1 PPHLN1 PXN RB1 RELA RHOA S100A7 SERPINF2 SERTAD1 SIPA1L2 SLC7A9 SMAD2 SMAD3 SPARC TAB2 TMEM176A TMSB4X TUBB ZNF512B
Entrez ID		5333	7052
HPRD ID		09073	01825
Ensembl ID		ENSG00000187091	ENSG00000198959
Uniprot IDs		A0A384MR47 A8K8F9 P51178	B4DIT7 B4DTN7 P21980 V9HWG3
PDB IDs			1FAU 1KV3 2Q3Z 3LY6 3S3J 3S3P 3S3S 4PYG 6A8P 6KZB
Enriched GO Terms of Interacting Partners?
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