PLAT and ANXA2

Number of citations of the paper that reports this interaction (PubMedID 11978811)
78

Data Source:
HPRD (in vitro, in vivo)

		PLAT	ANXA2
Description		plasminogen activator, tissue type	annexin A2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Cell Surface Secretory Granule Apical Part Of Cell Collagen-containing Extracellular Matrix Extracellular Exosome Schaffer Collateral - CA1 Synapse Glutamatergic Synapse	Ruffle Extracellular Region Basement Membrane Extracellular Space Nucleus Cytoplasm Lysosomal Membrane Endosome Early Endosome Lipid Droplet Cytosol Plasma Membrane Adherens Junction Cell Cortex Cell Surface Membrane Basolateral Plasma Membrane Extrinsic Component Of Plasma Membrane Midbody Late Endosome Membrane Vesicle Azurophil Granule Lumen Myelin Sheath Adaxonal Region Sarcolemma Melanosome Schmidt-Lanterman Incisure Macropinosome Membrane Raft Perinuclear Region Of Cytoplasm Collagen-containing Extracellular Matrix Extracellular Exosome AnxA2-p11 Complex PCSK9-AnxA2 Complex
	Molecular Function	Serine-type Endopeptidase Activity Signaling Receptor Binding Protein Binding Phosphoprotein Binding	Phosphatidylserine Binding Protease Binding RNA Binding Serine-type Endopeptidase Inhibitor Activity Calcium Channel Activity Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding Phosphatidylinositol-4,5-bisphosphate Binding Cytoskeletal Protein Binding Phospholipase A2 Inhibitor Activity Small GTPase Binding Identical Protein Binding S100 Protein Binding Bone Sialoprotein Binding Virion Binding Calcium-dependent Protein Binding Cadherin Binding Involved In Cell-cell Adhesion
	Biological Process	Response To Hypoxia Cellular Protein Modification Process Proteolysis Blood Coagulation Smooth Muscle Cell Migration Plasminogen Activation Fibrinolysis Negative Regulation Of Proteolysis Platelet-derived Growth Factor Receptor Signaling Pathway Prevention Of Polyspermy Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission	Angiogenesis Membrane Raft Assembly Positive Regulation Of Receptor Recycling Positive Regulation Of Protein Phosphorylation Vesicle Budding From Membrane Body Fluid Secretion Negative Regulation Of Endopeptidase Activity Collagen Fibril Organization Positive Regulation Of Vesicle Fusion Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Osteoclast Development Fibrinolysis Positive Regulation Of Vacuole Organization Positive Regulation Of Fibroblast Proliferation Calcium Ion Transmembrane Transport Protein Localization To Plasma Membrane Response To Thyroid Hormone Cell-cell Adhesion Positive Regulation Of Low-density Lipoprotein Particle Clearance Positive Regulation Of Low-density Lipoprotein Particle Receptor Binding Positive Regulation Of Low-density Lipoprotein Receptor Activity Positive Regulation Of Receptor-mediated Endocytosis Involved In Cholesterol Transport
Pathways		Signaling by PDGF Dissolution of Fibrin Clot	Smooth Muscle Contraction Neutrophil degranulation Dissolution of Fibrin Clot Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Drugs		Aminocaproic acid Iloprost Human C1-esterase inhibitor 5-(DIMETHYLAMINO)-2-NAPHTHALENESULFONIC ACID Dexibuprofen Conestat alfa	Tenecteplase Fluocinolone acetonide Lanoteplase Artenimol
Diseases
GWAS		Blood protein levels ( 30072576) Plasma plasminogen activator levels ( 24578379) Systemic lupus erythematosus ( 28714469)	Asthma ( 31959851) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Blood protein levels ( 30072576 28240269) Night sleep phenotypes ( 27126917) Type 2 diabetes ( 25102180)
Interacting Genes		37 interacting genes: ANXA2 APP BAG4 CALR CKAP4 CLEC3B CRABP1 CRTC1 DDHD2 EIF4EBP1 F10 FGA FN1 GML GRIN1 HMGB1 KRT8 LAMA1 LAMA3 LRP1 LRP1B MAPK1 MAPK3 MTDH PDGFC PLAU PLG PPP2CB PVR SART1 SERPINA5 SERPINE1 SERPING1 SERPINI1 SLC28A2 SPARC VDAC1	46 interacting genes: ACTA1 APOH APP CCDC32 CD99 CDC42 CEACAM1 CTSB CTSS DYSF GRB2 HMGA1 LGALS13 LINC01554 LYPLA1 MAP3K4 MYOC NOD2 OGDH PHB PLA1A PLA2G4A PLAT PLG POT1 PRKCA PRKCB PTEN RPS2 S100A10 S100A4 S100A6 SLC26A4-AS1 SMAD6 SMN1 SNX17 SOS1 SRC STAT6 TENT2 TERF1 TERT TNC TRPV5 YWHAQ ZBTB4
Entrez ID		5327	302
HPRD ID		01419	01061
Ensembl ID		ENSG00000104368	ENSG00000182718
Uniprot IDs		B4DN26 P00750	A0A024R5Z7 H0YL33 P07355
PDB IDs		1A5H 1BDA 1PK2 1PML 1RTF 1TPG 1TPK 1TPM 1TPN 5BRR 5ZLZ	1W7B 1XJL 2HYU 2HYV 2HYW 4DRW 4FTG 4HRH 5LPU 5LPX 5LQ0 5LQ2 5N7D 5N7F 5N7G 6TWQ 6TWU 6TWX 6TWY
Enriched GO Terms of Interacting Partners?
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