CDK12 and FNDC8

		CDK12	FNDC8
Description		cyclin dependent kinase 12	fibronectin type III domain containing 8
Image			No pdb structure
GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Cyclin K-CDK12 Complex Nucleus Nucleoplasm Cyclin/CDK Positive Transcription Elongation Factor Complex Nuclear Speck Nuclear Cyclin-dependent Protein Kinase Holoenzyme Complex	Nucleus
	Molecular Function	Protein Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Protein Kinase Binding Cyclin Binding Protein Serine Kinase Activity	Protein Binding
	Biological Process	Transcription Elongation From RNA Polymerase II Promoter MRNA Processing Protein Phosphorylation RNA Splicing Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter Regulation Of MAP Kinase Activity Regulation Of RNA Splicing Protein Autophosphorylation Regulation Of Cell Cycle Phosphorylation Of RNA Polymerase II C-terminal Domain Negative Regulation Of Stem Cell Differentiation
Pathways		TP53 Regulates Transcription of DNA Repair Genes
Drugs
Diseases
GWAS		Asthma ( 31619474) Blood urea nitrogen levels ( 31152163) Estimated glomerular filtration rate ( 31152163 30604766) Glomerular filtration rate ( 27588450) Glomerular filtration rate (creatinine) ( 28452372 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Lung function (FVC) ( 30061609) Menopause (age at onset) ( 26414677) Refractive error ( 32231278) Triglyceride levels ( 30108155)
Interacting Genes		19 interacting genes: AP1M2 CDKN1A CLK1 DDB1 EWSR1 FNDC8 GSDMB MBP PCDHB14 PCNT PDLIM7 PIN1 POLR2A PRPF40A RPL13 SLFN12 SRPK2 SRSF1 SRSF2	8 interacting genes: CDK12 GSDMB MAD2L1BP MBLAC1 MCRS1 PIK3R3 SMCO1 ZNF76
Entrez ID		51755	54752
HPRD ID		10849	13191
Ensembl ID		ENSG00000167258	ENSG00000073598
Uniprot IDs		Q9NYV4	Q8TC99
PDB IDs		4CXA 4NST 4UN0 5ACB 6B3E 6CKX 6TD3
Enriched GO Terms of Interacting Partners?
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