UIMC1 and NR6A1

Number of citations of the paper that reports this interaction (PubMedID 17416745)
43

Data Source:
HPRD (two hybrid, in vitro)

		UIMC1	NR6A1
Description		ubiquitin interaction motif containing 1	nuclear receptor subfamily 6 group A member 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Body BRCA1-A Complex	Chromatin Nucleoplasm Transcription Regulator Complex
	Molecular Function	DNA Binding Protein Binding Histone Binding Metal Ion Binding K63-linked Polyubiquitin Modification-dependent Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Nuclear Receptor Activity Zinc Ion Binding Protein Homodimerization Activity Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Double-strand Break Repair Mitotic G2 DNA Damage Checkpoint Signaling Response To Ionizing Radiation Positive Regulation Of DNA Repair Negative Regulation Of Transcription, DNA-templated Histone H2A K63-linked Deubiquitination	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Gamete Generation Intracellular Receptor Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Metalloprotease DUBs Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint
Drugs
Diseases
GWAS		Activated partial thromboplastin time ( 22703881) Menarche and menopause (age at onset) ( 19448621) Menopause (age at onset) ( 22267201 26414677 29773799) Uterine fibroids ( 31649266) Waist circumference adjusted for body mass index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Menarche (age at onset) ( 27182965)
Interacting Genes		23 interacting genes: ABRAXAS1 ATP8A2 BRCC3 CEP57 CREBBP DVL2 DYNLT3 ECPAS ESR1 FANCG H2AC20 INO80B MDC1 NR6A1 RAD23A SKIL SUMO2 TP53 UBB UBC USP13 WBP2 ZMYM3	6 interacting genes: DNMT3L GNB5 NCOA1 NCOR1 NSD1 UIMC1
Entrez ID		51720	2649
HPRD ID		11482	04147
Ensembl ID		ENSG00000087206	ENSG00000148200
Uniprot IDs		A0A024R7R0 Q96RL1	F1D8S0 F1DAM1 Q15406
PDB IDs		2MKF 2MKG 2N9E 2RR9
Enriched GO Terms of Interacting Partners?
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