TDP2 and TNFRSF8

Number of citations of the paper that reports this interaction (PubMedID 10764746)
47

Data Source:
HPRD (two hybrid, in vivo)

		TDP2	TNFRSF8
Description		tyrosyl-DNA phosphodiesterase 2	TNF receptor superfamily member 8
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Aggresome Nuclear Body PML Body	Cytoplasm Plasma Membrane Integral Component Of Membrane Extracellular Exosome
	Molecular Function	Magnesium Ion Binding Single-stranded DNA Binding Transcription Corepressor Activity Nuclease Activity Protein Binding Manganese Ion Binding Tyrosyl-RNA Phosphodiesterase Activity 5'-tyrosyl-DNA Phosphodiesterase Activity	Transmembrane Signaling Receptor Activity
	Biological Process	Double-strand Break Repair Cell Surface Receptor Signaling Pathway Negative Regulation Of Transcription, DNA-templated Neuron Development Nucleic Acid Phosphodiester Bond Hydrolysis	Signal Transduction Negative Regulation Of Cell Population Proliferation Positive Regulation Of TRAIL Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Apoptotic Process Cellular Response To Mechanical Stimulus
Pathways		Nonhomologous End-Joining (NHEJ)	TNFs bind their physiological receptors
Drugs			XmAb 2513 Brentuximab vedotin
Diseases
GWAS		Colorectal or endometrial cancer ( 26621817)	Asthma ( 31959851 34103634 32296059) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Mosquito bite size ( 28199695) Neutrophil percentage of granulocytes ( 27863252) Serum alkaline phosphatase levels ( 33339817) Sum eosinophil basophil counts ( 27863252) Tuberculosis ( 29036319)
Interacting Genes		37 interacting genes: AKAP9 ATP5MC2 ATXN1 BLK BTBD2 C2orf88 CD40 DLX3 DVL2 EPS8 ETS1 ETS2 FLI1 GOLGA2 JAM2 MAPK6 NOTCH4 PSEN1 RAB11A SKIL SMAD3 SNX13 SRPK2 SUMO1 SUMO2 SUMO3 TAP1 TFIP11 TNFRSF1B TNFRSF8 TRAF2 TRAF3 TRAF5 TRAF6 UBE2I WBP2 ZBED1	14 interacting genes: ALK CLCN6 EPHA2 HPCA PRDX4 RUNX3 SH3BGRL3 TDP2 TNFSF8 TRAF1 TRAF2 TRAF3 TRAF5 WRAP73
Entrez ID		51567	943
HPRD ID		05771	01074
Ensembl ID		ENSG00000111802	ENSG00000120949
Uniprot IDs		A0A384MDM5 O95551	A5D8T4 P28908
PDB IDs		5INO 5J3P 5J3S 6Q00 6Q01	1D01
Enriched GO Terms of Interacting Partners?
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