MBIP and WDR5

Number of citations of the paper that reports this interaction (PubMedID 16189514)
1103

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid)

		MBIP	WDR5
Description		MAP3K12 binding inhibitory protein 1	WD repeat domain 5
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Nucleolus Cytosol	Histone Acetyltransferase Complex Nucleus Nucleoplasm Histone Methyltransferase Complex MLL3/4 Complex Set1C/COMPASS Complex MLL1 Complex
	Molecular Function	Protein Kinase Inhibitor Activity Protein Binding Identical Protein Binding	Protein Binding Methylated Histone Binding Histone Binding Histone Methyltransferase Activity (H3-K4 Specific)
	Biological Process	Positive Regulation Of Gene Expression Negative Regulation Of Catalytic Activity Histone H3 Acetylation Positive Regulation Of JNK Cascade	Skeletal System Development Neuron Projection Development Histone H3 Acetylation Histone H4-K5 Acetylation Histone H4-K8 Acetylation Histone H4-K16 Acetylation Positive Regulation Of Gluconeogenesis Histone H3-K4 Methylation Positive Regulation Of Histone H3-K4 Methylation Negative Regulation Of Histone H3-K4 Methylation
Pathways		HATs acetylate histones	PKMTs methylate histone lysines HATs acetylate histones HATs acetylate histones RMTs methylate histone arginines Activation of anterior HOX genes in hindbrain development during early embryogenesis RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Neddylation
Drugs
Diseases
GWAS		Hypertension ( 31513605) Thyroid cancer ( 22267200) Thyroid hormone levels ( 23408906) Thyroid stimulating hormone levels ( 32769997 25743335)	Cerebrospinal fluid t-tau levels in normal cognition ( 29274321) Intraocular pressure ( 30591961)
Interacting Genes		47 interacting genes: BFSP2 CALM1 CCDC85B CCNC CEP63 COPS4 DGCR6 DGCR6L DIP2A DRC7 EPB41L3 EXOC8 FXR1 FXR2 ING5 KAT14 KLC3 LIMS1 LMNB1 LMO2 LMO3 MAP3K12 MAPK6 MCM7 MIS18A MOAP1 MYD88 NDEL1 NINL PIK3R3 PLEKHF2 POLR1C PPFIA1 RAP1GDS1 RAPGEF1 SHANK3 SMARCB1 STX11 TGIF2LY TRIM55 TRIM63 TSC1 TXLNA TXLNB VPS28 VTA1 WDR5	39 interacting genes: ADAMTS13 ANAPC2 APP ATN1 BBC3 BHLHE41 CHD8 DPAGT1 FAM199X H3-4 H4-16 HOTTIP HSF2 IGFBP3 IKBKG KMT2A MAN1B1 MARF1 MBIP MDM4 MEOX2 MLLT1 NELFB NOTCH2 NR2E3 PDE9A POU5F1 PRMT5 PRNP RUSC1-AS1 SPACA9 SRPK2 SRRM4 SSX2IP TERF2IP TP53 WWP2 ZBTB48 ZXDC
Entrez ID		51562	11091
HPRD ID		14368	10614
Ensembl ID		ENSG00000151332	ENSG00000196363
Uniprot IDs		B2RCV0 Q9NS73	P61964
PDB IDs			2CNX 2CO0 2G99 2G9A 2GNQ 2H13 2H14 2H68 2H6K 2H6N 2H6Q 2H9L 2H9M 2H9N 2H9P 2O9K 3EG6 3EMH 3MXX 3N0D 3N0E 3P4F 3PSL 3SMR 3UR4 3UVK 3UVL 3UVM 3UVN 3UVO 4A7J 4CY1 4CY2 4ERQ 4ERY 4ERZ 4ES0 4ESG 4EWR 4GM3 4GM8 4GM9 4GMB 4IA9 4O45 4QL1 4Y7R 5EAL 5EAM 5EAP 5EAR 5M23 5M25 5SXM 5VFC 6BYN 6D9X 6DAI 6DAK 6DAR 6DAS 6DY7 6DYA 6E1Y 6E1Z 6E22 6E23 6IAM 6KIU 6KIV 6KIW 6KIX 6KIZ 6OFZ 6OI0 6OI1 6OI2 6OI3 6PG3 6PG4 6PG5 6PG6 6PG7 6PG8 6PG9 6PGA 6PGB 6PGC 6PGD 6PGE 6PGF 6PWV 6PWW 6U5M 6U5Y 6U6W 6U80 6U8B 6U8L 6U8O 6UCS 6UFX 6UHY 6UHZ 6UIF 6UIK 6UJ4 6UJH 6UJJ 6UJL 6UOZ 6WJQ 7DNO
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?