PDE9A and NFIL3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		PDE9A	NFIL3
Description		phosphodiesterase 9A	nuclear factor, interleukin 3 regulated
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Ruffle Membrane Sarcolemma Perikaryon Perinuclear Region Of Cytoplasm	Chromatin Nucleus
	Molecular Function	3',5'-cyclic-nucleotide Phosphodiesterase Activity Protein Binding Metal Ion Binding 3',5'-cyclic-GMP Phosphodiesterase Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding
	Biological Process	Signal Transduction Positive Regulation Of Cardiac Muscle Hypertrophy CGMP-mediated Signaling CGMP Metabolic Process CGMP Catabolic Process	Negative Regulation Of Transcription By RNA Polymerase II Natural Killer Cell Differentiation Regulation Of Transcription, DNA-templated Transcription By RNA Polymerase II Immune Response Circadian Rhythm Positive Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Cellular Response To Interleukin-4
Pathways		cGMP effects	Circadian Clock
Drugs		Caffeine gamma-Glutamyl[S-(2-iodobenzyl)cysteinyl]glycine 3-isobutyl-1-methyl-7H-xanthine Trapidil
Diseases
GWAS		Hematocrit ( 32888494) Hemoglobin ( 32888494) Perceived unattractiveness to mosquitoes ( 28199695)	Bipolar disorder (inflammation and infection response interaction) ( 25781172) Birth weight ( 31043758) Inflammatory bowel disease ( 23128233) Offspring birth weight ( 31043758)
Interacting Genes		41 interacting genes: BAG3 CDC37 CLK1 CRY2 CYSRT1 ERG FXR1 FXR2 GORASP2 IQCB1 KANK2 KRT34 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-2 KRTAP12-3 KRTAP4-2 KRTAP5-9 KRTAP9-2 LAGE3 LINC02913 LMO2 MX1 NAA38 NFIL3 NOTCH2NLA PCNT PHYHIPL PRPF18 SDCBP SULT1E1 TFAP4 TRIM32 TRPV6 UBD UTP23 WDR5	16 interacting genes: AMOTL2 BATF CREB3 DDIT3 DELEC1 DNMT3L DR1 FHL1 GMCL1 HSF2BP MAFF MAFG PDE9A PIH1D2 RINT1 TRAF2
Entrez ID		5152	4783
HPRD ID		09115	05619
Ensembl ID		ENSG00000160191	ENSG00000165030
Uniprot IDs		A0A0S2Z475 A0A0S2Z4A3 A0A0S2Z4T6 O76083	A0A024R241 Q16649
PDB IDs		2HD1 2YY2 3DY8 3DYL 3DYN 3DYQ 3DYS 3JSI 3JSW 3K3E 3K3H 3N3Z 3QI3 3QI4 4E90 4G2J 4G2L 4GH6 4Y86 4Y87 4Y8C 6A3N 6LZZ
Enriched GO Terms of Interacting Partners?
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