ECSIT and LOXL4

Number of citations of the paper that reports this interaction (PubMedID 21163940)
36

Data Source:
BioGRID (two hybrid)

		ECSIT	LOXL4
Description		ECSIT signaling integrator	lysyl oxidase like 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Inner Membrane Cytosol	Extracellular Space Membrane Receptor Complex Extracellular Exosome
	Molecular Function	Protein Binding	Protein-lysine 6-oxidase Activity Scavenger Receptor Activity Copper Ion Binding Protein Binding
	Biological Process	Innate Immune Response Regulation Of Oxidoreductase Activity Regulation Of Protein Complex Stability	Endocytosis Peptidyl-lysine Oxidation Collagen Fibril Organization
Pathways		MyD88:MAL(TIRAP) cascade initiated on plasma membrane Complex I biogenesis TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88 cascade initiated on plasma membrane	Elastic fibre formation Crosslinking of collagen fibrils
Drugs
Diseases
GWAS		Presence of antiphospholipid antibodies ( 27098658)	Body mass index ( 29273807) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Height ( 31562340) Multiple system atrophy ( 27629089) Serum metabolite levels ( 33031748)
Interacting Genes		61 interacting genes: A2M AP1M2 APOE APP BFSP2 BLMH C1orf109 CDC37 CEP55 CNN1 CORO2B CTNNA3 CYP2C18 CYP2C8 CYP2C9 DNAJB1 DTX2 DYNC1H1 ELAVL3 EXOC6 EXOSC1 FARSA FBXL12 FBXW4 GCDH GEM IFIT3 IFIT5 IMMT LONP1 LOXL4 MAGEB2 MARCHF2 MAST1 MKRN3 MRPL4 NDUFA13 NFKB1 NXF1 OGT PAXIP1 PI4K2A PRDX2 PSEN1 RAB3A RAD23A RELA RHEB RNF32 SELPLG SETDB1 SHFL SMAD1 SMAD4 SMURF1 STAMBPL1 STRN4 TARS3 TRAF6 TRIM59 TSSK3	15 interacting genes: AP1M2 APOE CDC37 COL2A1 ECSIT EXOC6 KDM1A LONP1 MAST1 MTDH PRMT6 RAD23A RNF32 SUV39H1 TRIP13
Entrez ID		51295	84171
HPRD ID		12225	09538
Ensembl ID		ENSG00000130159	ENSG00000138131
Uniprot IDs		Q9BQ95	Q96JB6
PDB IDs
Enriched GO Terms of Interacting Partners?
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