GMIP and ARHGAP45

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		GMIP	ARHGAP45
Description		GEM interacting protein	Rho GTPase activating protein 45
Image
GO Annotations	Cellular Component	Nucleoplasm Cytosol Plasma Membrane	Extracellular Region Cytosol Membrane Ruffle Membrane Secretory Granule Lumen Azurophil Granule Lumen
	Molecular Function	GTPase Activator Activity Protein Binding Metal Ion Binding	GTPase Activator Activity Protein Binding Metal Ion Binding
	Biological Process	Negative Regulation Of GTPase Activity Intracellular Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Activation Of GTPase Activity	Intracellular Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Activation Of GTPase Activity
Pathways		RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle	Neutrophil degranulation RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle
Drugs
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Bipolar II disorder ( 31043756) LDL cholesterol levels ( 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Lymphocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494) Refractive error ( 32231278) Schizophrenia ( 23974872) Triglyceride levels ( 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
Interacting Genes		5 interacting genes: ARHGAP45 CDC42 GEM RAC1 RHOA	10 interacting genes: BICD2 GMIP GOLGA2 HSF2BP PIBF1 PPP1R13B RINT1 RPL36 TRIM50 ZUP1
Entrez ID		51291	23526
HPRD ID		11005	03097
Ensembl ID		ENSG00000089639	ENSG00000180448
Uniprot IDs		A0A024R7N1 B4DLZ1 Q9P107	B3KVA9 B3KXW7 F5H1R4 K7ES92 K7ES98 Q8IYN3 Q92619
PDB IDs		3QWE	3D25 3FT3
Enriched GO Terms of Interacting Partners?
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