PLEKHO1 and DNAJB1

Number of citations of the paper that reports this interaction (PubMedID 18624398)
18

Data Source:
BioGRID (two hybrid)

		PLEKHO1	DNAJB1
Description		pleckstrin homology domain containing O1	DnaJ heat shock protein family (Hsp40) member B1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Ruffle Membrane Muscle Cell Projection Membrane	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Postsynaptic Density Neuronal Cell Body Dendritic Spine Sperm Head Extracellular Exosome Glutamatergic Synapse
	Molecular Function	Protein Binding	ATPase Activator Activity Transcription Corepressor Activity Protein Binding Hsp70 Protein Binding Protein Folding Chaperone Cadherin Binding Unfolded Protein Binding Chaperone Binding ATPase Binding
	Biological Process	Myoblast Fusion Regulation Of Cell Shape Myoblast Migration Lamellipodium Morphogenesis Regulation Of Myoblast Fusion	Negative Regulation Of Transcription By RNA Polymerase II Response To Unfolded Protein Forebrain Development Positive Regulation Of ATPase Activity Regulation Of Catalytic Activity Chaperone Cofactor-dependent Protein Refolding Negative Regulation Of Inclusion Body Assembly Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of Cellular Response To Heat
Pathways			Regulation of HSF1-mediated heat shock response HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Attenuation phase HSF1-dependent transactivation MAPK6/MAPK4 signaling
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)	Adventurousness ( 30643258) General risk tolerance (MTAG) ( 30643258)
Interacting Genes		40 interacting genes: ADAM33 ADAMTSL4 AKT1 AKT2 BNIP2 BRICD5 C10orf88 C1orf56 C4orf3 CDC42SE1 CEP19 COL8A2 CSNK2A1 CYP4F2 DNAJB1 FLNB GOLPH3L IFI35 LRP10 MMD NAPB OGT PSMC5 RPRD2 RPS20 SMAD5 SMG5 SMURF1 SYT11 THSD7B TMEM218 TNF TRAF3IP3 TRAF6 TRAM1L1 TSPAN33 TSPO2 USP7 VAMP3 ZFPL1	31 interacting genes: A2M AKT1 ANK2 APP BDKRB1 BRCA1 BRMS1 CENPE CYP2C8 DNAJC3 DNM2 ECSIT FANCA FANCC GLB1 GSK3A HSF1 HSPA1A MAST1 NQO1 NRAS PEA15 PLEKHO1 PSEN2 PTGES3 SOD1 SPP1 STUB1 TERF1 TTLL12 ZFP36
Entrez ID		51177	3337
HPRD ID		12217	05198
Ensembl ID		ENSG00000023902	ENSG00000132002
Uniprot IDs		Q53GL0 Q5T4P9	P25685 Q6FHS4
PDB IDs		3AA1	1HDJ 2QLD 3AGX 3AGY 3AGZ 4WB7 6BYR 6WJF 6WJG 6Z5N
Enriched GO Terms of Interacting Partners?
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