SEPSECS and ANAPC4

		SEPSECS	ANAPC4
Description		Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase	anaphase promoting complex subunit 4
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nucleus Nucleoplasm Anaphase-promoting Complex Cytosol Nuclear Periphery
	Molecular Function	TRNA Binding Protein Binding Phosphoseryl-selenocysteinyl-tRNA Selenium Transferase Activity	Ubiquitin-protein Transferase Activity Protein Binding Protein Phosphatase Binding
	Biological Process	Selenocysteine Incorporation Selenocysteinyl-tRNA(Sec) Biosynthetic Process	Cell Cycle Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition Cell Division Protein K11-linked Ubiquitination
Pathways		Selenocysteine synthesis	Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Pyridoxal phosphate
Diseases
GWAS		Tonsillectomy ( 27182965 28928442)	Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Body mass index ( 29273807) Body size at age 10 ( 32376654) General cognitive ability ( 29844566) Heel bone mineral density ( 30598549) Intelligence (MTAG) ( 29326435) Logical memory (immediate recall) in normal cognition ( 29274321) Multisite chronic pain ( 31194737) Waist circumference adjusted for body mass index ( 34021172) Weight ( 20966902)
Interacting Genes		3 interacting genes: ANAPC4 DNAH1 DTX2	8 interacting genes: ANAPC11 CDC20 CDC27 MAD2L1 MAD2L1BP SEPSECS UBE2I UBE2S
Entrez ID		51091	29945
HPRD ID		11561	09505
Ensembl ID		ENSG00000109618	ENSG00000053900
Uniprot IDs		A1A4F3 Q9HD40	B3KN47 Q9UJX5
PDB IDs		3HL2 4ZDL 4ZDO 4ZDP	4UI9 5A31 5BPW 5G04 5G05 5KHR 5KHU 5L9T 5L9U 5LCW 6Q6G 6Q6H 6TLJ 6TM5 6TNT
Enriched GO Terms of Interacting Partners?
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