PCM1 and RPA2

Number of citations of the paper that reports this interaction (PubMedID 30217970)
5

Data Source:
BioGRID (two hybrid)

		PCM1	RPA2
Description		pericentriolar material 1	replication protein A2
Image
GO Annotations	Cellular Component	Pericentriolar Material Cytoplasm Centrosome Centriole Cytosol Membrane Nuclear Membrane Protein-containing Complex Centriolar Satellite Ciliary Transition Zone Ciliary Basal Body Apical Part Of Cell Non-motile Cilium	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm DNA Replication Factor A Complex Nuclear Body PML Body Site Of Double-strand Break
	Molecular Function	Protein Binding Identical Protein Binding	Damaged DNA Binding Single-stranded DNA Binding Protein Binding Enzyme Binding Protein Phosphatase Binding Ubiquitin Protein Ligase Binding Protein N-terminus Binding G-rich Strand Telomeric DNA Binding
	Biological Process	Neuron Migration Centrosome Cycle Interkinetic Nuclear Migration Cytoplasmic Microtubule Organization Microtubule Anchoring Microtubule Anchoring At Centrosome Social Behavior Intraciliary Transport Involved In Cilium Assembly Negative Regulation Of Neurogenesis Cilium Assembly Protein Localization To Centrosome Positive Regulation Of Intracellular Protein Transport Neuronal Stem Cell Population Maintenance Non-motile Cilium Assembly	Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Replication Base-excision Repair Nucleotide-excision Repair Mismatch Repair Regulation Of Double-strand Break Repair Via Homologous Recombination Mitotic G1 DNA Damage Checkpoint Signaling Protein Localization To Chromosome Regulation Of DNA Damage Checkpoint
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2	Translesion synthesis by REV1 Recognition of DNA damage by PCNA-containing replication complex Translesion Synthesis by POLH Removal of the Flap Intermediate from the C-strand Activation of ATR in response to replication stress Regulation of HSF1-mediated heat shock response HSF1 activation Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) PCNA-Dependent Long Patch Base Excision Repair Translesion synthesis by POLK Translesion synthesis by POLI Termination of translesion DNA synthesis HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Formation of Incision Complex in GG-NER Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Fanconi Anemia Pathway Regulation of TP53 Activity through Phosphorylation Activation of the pre-replicative complex Removal of the Flap Intermediate G2/M DNA damage checkpoint Meiotic recombination
Drugs
Diseases
GWAS		Atrial fibrillation ( 28416818) Economic and political preferences ( 22566634) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Triglyceride levels ( 32203549) Waist-hip ratio ( 30108283) Weight ( 28552196)	HDL cholesterol levels ( 32203549) Platelet count ( 32888494) Plateletcrit ( 32888494) White blood cell count ( 32888494)
Interacting Genes		47 interacting genes: ABI1 ABI2 AKAP9 BBS4 CASK CCDC172 CCHCR1 CDC42 CEP72 CYTH4 DDIT3 DDX23 DPYSL2 DYNLL1 E2F4 ECPAS EPS8 EXOC8 FAM81A FGF20 FXR2 GABARAP GOLGA2 HAP1 ING5 KLC1 KLC4 KRT15 KRT19 KRT24 MCRS1 NECAB2 PCNT PDGFRL PRC1 PRKCI PXN RALBP1 RBM5 RINT1 RPA2 TFIP11 TNFRSF10B TTC8 WASHC3 YWHAE YWHAQ	65 interacting genes: ACP5 AKAP9 APP ATM CALCOCO2 CASK CCNC CCNO CDC5L CDK1 CEP126 CFB COPS6 CRMP1 DMRTB1 EEF1A1 EIF4G2 ERCC1 ERCC4 GAPDH GOLM1 HERPUD1 HNRNPUL1 HUS1 LNX2 LRIF1 MARK2 MCM2 MCM5 MED1 MED31 MEN1 NDEL1 ORC1 ORC2 ORC4 ORC5 PCM1 PIAS1 PIAS4 PPP4C PRC1 PRKCI PRKDC RAD1 RAD51 RAD52 RAD9A RBM14 RBM48 RPA1 RPA3 RPLP1 SDF4 SERTAD3 SLC17A9 STAT3 TLE1 TUBB2A UNC119 UNG UTP14A XPA YWHAE ZBTB14
Entrez ID		5108	6118
HPRD ID		02624	01566
Ensembl ID		ENSG00000078674	ENSG00000117748
Uniprot IDs		A2RUU9 B9EIS5 Q15154	B4DUL2 P15927
PDB IDs		6HYL 6HYM	1DPU 1L1O 1QUQ 1Z1D 2PI2 2PQA 2Z6K 3KDF 4MQV 4OU0
Enriched GO Terms of Interacting Partners?
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