SERPINA5 and F11

Number of citations of the paper that reports this interaction (PubMedID 2551064)
20

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		SERPINA5	F11
Description		serpin family A member 5	coagulation factor XI
Image
GO Annotations	Cellular Component	Acrosomal Membrane Extracellular Region Extracellular Space External Side Of Plasma Membrane Membrane Platelet Alpha Granule Platelet Dense Tubular Network Protein-containing Complex Protein C Inhibitor-TMPRSS7 Complex Protein C Inhibitor-TMPRSS11E Complex Protein C Inhibitor-PLAT Complex Protein C Inhibitor-PLAU Complex Protein C Inhibitor-thrombin Complex Protein C Inhibitor-KLK3 Complex Protein C Inhibitor-plasma Kallikrein Complex Collagen-containing Extracellular Matrix Extracellular Exosome Protein C Inhibitor-coagulation Factor V Complex Protein C Inhibitor-coagulation Factor Xa Complex Protein C Inhibitor-coagulation Factor XI Complex	Extracellular Region Extracellular Space Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	Retinoic Acid Binding Protease Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding Glycosaminoglycan Binding Heparin Binding Phosphatidylcholine Binding Acrosin Binding	Serine-type Endopeptidase Activity Protein Binding Heparin Binding Serine-type Aminopeptidase Activity
	Biological Process	Lipid Transport Spermatogenesis Fusion Of Sperm To Egg Plasma Membrane Involved In Single Fertilization Negative Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Seminal Vesicle Development	Blood Coagulation Plasminogen Activation Positive Regulation Of Fibrinolysis
Pathways		Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation	Intrinsic Pathway of Fibrin Clot Formation Defective F9 activation
Drugs		Urokinase Drotrecogin alfa Tifuvirtide PPL-100	Coagulation Factor IX (Recombinant) Human C1-esterase inhibitor 3-Hydroxypropyl 3-[(7-carbamimidoyl-1-naphthyl)carbamoyl]benzenesulfonate (1R)-2-[(Diaminomethylene)amino]-1-{4-[(4R)-4-(hydroxymethyl)-1,3,2-dioxaborolan-2-yl]phenyl}ethyl nicotinate (R)-1-(4-(4-(Hydroxymethyl)-1,3,2-dioxaborolan-2-YL)phenethyl)guanidine 6-CARBAMIMIDOYL-4-(3-HYDROXY-2-METHYL-BENZOYLAMINO)-NAPHTHALENE-2-CARBOXYLIC ACID METHYL ESTER (R)-1-(4-(4-(Hydroxymethyl)-1,3,2-dioxaborolan-2-YL)phenyl)guanidine N-(7-CARBAMIMIDOYL-NAPHTHALEN-1-YL)-3-HYDROXY-2-METHYL-BENZAMIDE 4-METHYL-PENTANOIC ACID {1-[4-GUANIDINO-1-(THIAZOLE-2-CARBONYL)-BUTYLCARBAMOYL]-2-METHYL-PROPYL}-AMIDE (R)-1-(4-(4-(hydroxymethyl)-1,3,2-dioxaborolan-2-yl)benzyl)guanidine Conestat alfa Thrombin Human thrombin Coagulation Factor IX Human Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Blood protein levels ( 30072576 29875488 28240269) Serum albumin level ( 29403010) Serum total protein level ( 29403010)	Activated partial thromboplastin time ( 22703881 29403010) Blood protein levels ( 28240269) Cardiac troponin-I levels ( 31014085) Factor XI ( 28053049) Ischemic stroke (cardioembolic) ( 29531354) L-arginine levels ( 27656708) Response to statin therapy ( 20339536) Serum metabolite concentrations in chronic kidney disease ( 33838163) Thrombosis ( 26908601) Venous thromboembolism ( 21980494 23650146 25772935 28373160 31420334 31676865)
Interacting Genes		23 interacting genes: ACR CBL COPS6 EPS8 F10 F11 F2 FBLN5 FGA FGB FGG KLK1 KLK2 KLK3 KLKB1 PIAS4 PLAT PLAU PROC RCHY1 RIDA SEMG2 THBD	8 interacting genes: DNAJC19 F2 GP1BA HGF KNG1 SERPINA5 SERPINF2 TFPI2
Entrez ID		5104	2160
HPRD ID		03503	07524
Ensembl ID		ENSG00000188488	ENSG00000088926
Uniprot IDs		A0A024R6N9 B4DDH1 P05154	P03951
PDB IDs		1LQ8 1PAI 2HI9 2OL2 2PAI 3DY0	1XX9 1XXD 1XXF 1ZHM 1ZHP 1ZHR 1ZJD 1ZLR 1ZMJ 1ZML 1ZMN 1ZOM 1ZPB 1ZPC 1ZPZ 1ZRK 1ZSJ 1ZSK 1ZSL 1ZTJ 1ZTK 1ZTL 2F83 2FDA 2J8J 2J8L 3BG8 3SOR 3SOS 4CR5 4CR9 4CRA 4CRB 4CRC 4CRD 4CRE 4CRF 4CRG 4D76 4D7F 4D7G 4NA7 4NA8 4TY6 4TY7 4WXI 4X6M 4X6N 4X6O 4X6P 4Y8X 4Y8Y 4Y8Z 5E2O 5E2P 5EOD 5EOK 5EXL 5EXM 5EXN 5I25 5Q0D 5Q0E 5Q0F 5Q0G 5Q0H 5QCK 5QCL 5QCM 5QCN 5QQO 5QQP 5QTT 5QTV 5QTW 5QTY 5TKS 5TKT 5TKU 5WB6 6AOD 6C0S 6HHC 6I58 6R8X 6TS4 6TS5 6TS6 6TS7 6TWB 6USY 6VLU 6VLV 6W50
Enriched GO Terms of Interacting Partners?
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