PCDH9 and HTR2A

		PCDH9	HTR2A
Description		protocadherin 9	5-hydroxytryptamine receptor 2A
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GO Annotations	Cellular Component	Integral Component Of Plasma Membrane Growth Cone Cell-cell Contact Zone	Cytosol Plasma Membrane Integral Component Of Plasma Membrane Caveola Axon Dendrite Cytoplasmic Vesicle Neuronal Cell Body Dendritic Shaft Cell Body Fiber G Protein-coupled Serotonin Receptor Complex Glutamatergic Synapse Integral Component Of Postsynaptic Membrane Integral Component Of Presynaptic Membrane
	Molecular Function	Calcium Ion Binding	Gq/11-coupled Serotonin Receptor Activity Virus Receptor Activity G Protein-coupled Serotonin Receptor Activity Protein Binding Neurotransmitter Receptor Activity Identical Protein Binding Protein-containing Complex Binding Serotonin Binding 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine Binding
	Biological Process	Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Forebrain Development	Temperature Homeostasis Cellular Calcium Ion Homeostasis G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Phospholipase C-activating Serotonin Receptor Signaling Pathway Serotonin Receptor Signaling Pathway Chemical Synaptic Transmission Aging Memory Cell Death Positive Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Positive Regulation Of Phosphatidylinositol Biosynthetic Process Regulation Of Dopamine Secretion Phosphatidylinositol 3-kinase Signaling Artery Smooth Muscle Contraction Urinary Bladder Smooth Muscle Contraction Sleep Negative Regulation Of Potassium Ion Transport Positive Regulation Of MAP Kinase Activity Protein Localization To Cytoskeleton Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Glycolytic Process Positive Regulation Of Vasoconstriction Viral Entry Into Host Cell Behavioral Response To Cocaine Positive Regulation Of Peptidyl-tyrosine Phosphorylation Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of ERK1 And ERK2 Cascade G Protein-coupled Serotonin Receptor Signaling Pathway Regulation Of Synaptic Vesicle Exocytosis
Pathways			Serotonin receptors G alpha (q) signalling events
Drugs			Ziprasidone Methysergide Cabergoline Zolmitriptan Amitriptyline Olanzapine Clozapine Mirtazapine Loxapine Remoxipride Promazine Cyproheptadine Imipramine Chlorpromazine Chlorpromazine Haloperidol Nortriptyline Amoxapine Lamotrigine Fenfluramine Lisuride Cisapride Fluphenazine Trazodone Thioridazine Ergotamine Apomorphine Paroxetine Paroxetine Trimipramine Risperidone Epinastine Propiomazine Minaprine Donepezil Flupentixol Cyclobenzaprine Mesoridazine Maprotiline Ergoloid mesylate Tegaserod Doxepin Nefazodone Desipramine Escitalopram Pergolide Bromocriptine Ketamine Quetiapine Aripiprazole Chlorprothixene Chlorprothixene Clomipramine Paliperidone Yohimbine Methotrimeprazine MMDA Midomafetamine Dimethyltryptamine 4-Bromo-2,5-dimethoxyphenethylamine Acepromazine Molindone Pipotiazine Thioproperazine Thiothixene Zuclopenthixol Aniracetam Fluspirilene Flibanserin Iloperidone HY10275 APD791 Pimavanserin Epicept NP-1 BL-1020 Cariprazine Lumateperone YKP-1358 Sertindole Mianserin Pizotifen Asenapine Ocaperidone Amisulpride Dotarizine Deramciclane Esmirtazapine Cinitapride Lurasidone Serotonin Perospirone Amperozide Butriptyline Cannabidiol Brexpiprazole Dosulepin Etoperidone Lorpiprazole Blonanserin Zotepine Pipamperone Setiptiline Dihydroergocornine Gilteritinib Sarpogrelate Eplivanserin Ketanserin Nelotanserin Ritanserin Tiapride Dihydroergocristine 2,5-Dimethoxy-4-ethylthioamphetamine N-(2-hydroxybenzyl)-2,5-dimethoxy-4-cyanophenylethylamine Medical Cannabis 5-methoxy-N,N-dimethyltryptamine Nabiximols Aripiprazole lauroxil
Diseases
GWAS		Adult body size ( 32376654) Age at first birth ( 34211149) Blood protein levels ( 30072576) Body size at age 10 ( 32376654) Chronotype ( 30696823) Clostridioides difficle infection ( 33841421) Current cigarettes per day in chronic obstructive pulmonary disease ( 29631575) Dental caries ( 23064961) Feeling nervous ( 29500382) Forced expiratory volume in 1 second (occupational environmental exposures interaction) ( 25979521) Gastroesophageal reflux disease ( 34187846) General factor of neuroticism ( 30867560) Insomnia ( 29520036) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Latent naming speed ( 30995994) Major depressive disorder ( 27479909) Male fertility ( 22633400) Metabolite levels ( 23823483) Obesity ( 21552555) Photic sneeze reflex ( 27182965) Postoperative survival time in hepatocellular carcinoma ( 30945673 30945699) Pulmonary function decline ( 22424883) Recalcitrant atopic dermatitis ( 25935106) Refractive error ( 32231278) Response to platinum-based chemotherapy (cisplatin) ( 21844884) Sense of smell ( 26632684) Smoking initiation ( 33082346) Smoking status (ever vs never smokers) ( 30643258)	Blood protein levels ( 28240269) Cardiac hypertrophy ( 21348951) Parkinson disease and lewy body pathology ( 25663231) Serum 25-Hydroxyvitamin D levels ( 29325163) SjÃ¶gren's syndrome ( 28076899) Subcutaneous adipose tissue ( 22589738)
Interacting Genes		3 interacting genes: CYSLTR2 HTR2A MEOX2	25 interacting genes: ANKS1B ARF1 ARF6 CTSG DACH1 DIRAS3 DLG1 DLG4 EIF3F GLUL GNA11 GNAI1 GNAQ JAK2 MAP1A MRPL28 NDUFB10 NME3 NTRK3 PCDH9 PON2 PPP5C RFXAP RPS6KA3 SUGT1
Entrez ID		5101	3356
HPRD ID		04661	01638
Ensembl ID		ENSG00000184226	ENSG00000102468
Uniprot IDs		A7E2D9 B7ZM79 Q5VT82 Q9HC56 X5D7N0	P28223
PDB IDs		2EE0	6A93 6A94 6WGT 6WH4 6WHA
Enriched GO Terms of Interacting Partners?
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