PCDH7 and RFC1

		PCDH7	RFC1
Description		protocadherin 7	replication factor C subunit 1
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Platelet Alpha Granule Membrane	Nucleus Nucleoplasm DNA Replication Factor C Complex Nucleolus Cytoplasm Elg1 RFC-like Complex Extracellular Exosome
	Molecular Function	Calcium Ion Binding	DNA Binding DNA Clamp Loader Activity Double-stranded DNA Binding Protein Binding ATP Binding Enzyme Activator Activity Protein Domain Specific Binding Sequence-specific DNA Binding DNA Clamp Unloader Activity
	Biological Process	Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules	Negative Regulation Of Transcription By RNA Polymerase II DNA-dependent DNA Replication DNA Repair Telomere Maintenance Via Telomerase Positive Regulation Of Transcription, DNA-templated Regulation Of Catalytic Activity DNA Clamp Unloading
Pathways		Platelet degranulation RHOA GTPase cycle RHOB GTPase cycle	Translesion synthesis by REV1 Recognition of DNA damage by PCNA-containing replication complex Translesion Synthesis by POLH Polymerase switching on the C-strand of the telomere PCNA-Dependent Long Patch Base Excision Repair Translesion synthesis by POLK Translesion synthesis by POLI Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Polymerase switching
Drugs
Diseases
GWAS		Adult body size ( 32376654) Adventurousness ( 30643258) Alzheimer's disease (late onset) ( 30820047) Attention deficit hyperactivity disorder ( 32279069) Body size at age 10 ( 32376654) Depressive symptom (sleep problems) (binary trait) ( 31530331) Diastolic blood pressure x smoking status (ever vs never) interaction (1df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Diffusing capacity of carbon monoxide ( 30694715) Electroencephalogram traits ( 25387704) Epilepsy ( 25087078) General risk tolerance (MTAG) ( 30643258) Generalized epilepsy ( 30531953) Hip circumference adjusted for BMI ( 28552196) Influenza A (H1N1) infection ( 26379185) Lipid traits ( 22028671) Mean arterial pressure x educational attainment (some college) interaction (2df) ( 32372009) Menarche (age at onset) ( 25231870) Mild influenza (H1N1) infection ( 26379185) Mouth morphology (principal component model) ( 30174134) Number of sexual partners ( 30643258) Obesity-related traits ( 23251661) Refractive astigmatism ( 25367360) Refractive error ( 32231278) Response to antipsychotic treatment in schizophrenia ( 29503163) Response to ziprazidone in schizophrenia ( 29503163) Smoking status (ever vs never smokers) ( 30643258) Triglyceride levels ( 34074324) Underweight status ( 25133637) Very long-chain saturated fatty acid levels (fatty acid 22:0) ( 25378659) White matter hyperintensities in ischemic stroke ( 26674333)	Asthma ( 30929738) Asthma (adult onset) ( 30929738) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Reticulocyte count ( 32888494)
Interacting Genes		9 interacting genes: BST1 CD38 MTDH PDLIM5 PPARGC1A PPP1CA RFC1 RPIA SPP1	20 interacting genes: BRCA1 BRD4 CASP3 CCND1 CDK4 CEBPA CSNK2B HDAC1 MYOC PCDH7 PCNA RELA RFC2 RFC3 SMC1A SSBP3 TCEAL1 UBC YWHAQ ZSCAN1
Entrez ID		5099	5981
HPRD ID		04288	00024
Ensembl ID		ENSG00000169851	ENSG00000035928
Uniprot IDs		O60245	P35251
PDB IDs		2YST	2EBU 2K6G 2K7F 6VVO
Enriched GO Terms of Interacting Partners?
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