SHANK1 and ADGRL2

Number of citations of the paper that reports this interaction (PubMedID 10964907)
26

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SHANK1	ADGRL2
Description		SH3 and multiple ankyrin repeat domains 1	adhesion G protein-coupled receptor L2
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Postsynaptic Density Membrane Dendrite Neuron Projection Dendritic Spine Postsynaptic Membrane Excitatory Synapse Schaffer Collateral - CA1 Synapse Glutamatergic Synapse	Integral Component Of Plasma Membrane Integral Component Of Membrane Neuron Projection Glutamatergic Synapse Integral Component Of Postsynaptic Membrane
	Molecular Function	Protein Binding Protein C-terminus Binding SH3 Domain Binding Synaptic Receptor Adaptor Activity Somatostatin Receptor Binding Ionotropic Glutamate Receptor Binding Identical Protein Binding Protein-containing Complex Binding Ankyrin Repeat Binding Scaffold Protein Binding	G Protein-coupled Receptor Activity Latrotoxin Receptor Activity Carbohydrate Binding
	Biological Process	Long-term Memory Associative Learning Adult Behavior Negative Regulation Of Actin Filament Bundle Assembly Social Behavior Protein Localization To Synapse Olfactory Behavior Habituation Neuromuscular Process Controlling Balance Determination Of Affect Righting Reflex Synapse Maturation Dendritic Spine Morphogenesis Positive Regulation Of Dendritic Spine Development Protein-containing Complex Assembly Vocalization Behavior Regulation Of AMPA Receptor Activity Positive Regulation Of Excitatory Postsynaptic Potential	Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Brain Development Response To Bacterium Synapse Organization Positive Regulation Of Synapse Assembly
Pathways		Neurexins and neuroligins Neurexins and neuroligins
Drugs
Diseases
GWAS		Carotid plaque maximum area ( 32469969) Clozapine-induced cytotoxicity ( 25656473) Sum of carotid plaque area ( 32469969) Sum of stenosis ( 32469969)	Cataracts ( 34127677) Clozapine-induced agranulocytosis/granulocytopenia in treatment-resistant schizophrenia ( 27400856) Estimated glomerular filtration rate after 5 years in renal transplantation (recipient effect) ( 30920136) Impaired insulin sensitivity in response to n-3 PUFA supplementation ( 31779001) Low density lipoprotein cholesterol levels ( 30498476) Major depressive episode treated with electroconvulsive therapy ( 33483693)
Interacting Genes		22 interacting genes: ABCA1 ACE2 ADGRB2 ADGRL1 ADGRL2 ARHGEF7 BAIAP2 DLG4 DLGAP1 DNM2 FXR1 HOMER1 RPS6KA2 RPS6KA3 SHANK3 SHARPIN SPTAN1 SSTR2 STAT1 TANC1 TSC1 USP8	4 interacting genes: MUC1 NCK1 SHANK1 SHANK2
Entrez ID		50944	23266
HPRD ID		05413	06116
Ensembl ID		ENSG00000161681	ENSG00000117114
Uniprot IDs		H9KV90 Q9Y566	A0A6I8PTT2 O95490
PDB IDs		6CPI 6YWZ 6YX0 6YX1 6YX2
Enriched GO Terms of Interacting Partners?
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Tagcloud (Difference) ?
Tagcloud (Intersection) ?