NTM and SPRY1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		NTM	SPRY1
Description		neurotrimin	sprouty RTK signaling antagonist 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Anchored Component Of Membrane	Nucleoplasm Golgi Apparatus Cytosol Plasma Membrane
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Cell Adhesion Neuron Recognition	Establishment Of Mitotic Spindle Orientation Metanephros Development Ureteric Bud Development Organ Induction Negative Regulation Of Cell Population Proliferation Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of GTPase Activity Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Negative Regulation Of MAP Kinase Activity Negative Regulation Of Ras Protein Signal Transduction Animal Organ Development Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Bud Elongation Involved In Lung Branching Epithelial To Mesenchymal Transition Involved In Cardiac Fibroblast Development Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Lens Fiber Cell Differentiation
Pathways		Post-translational modification: synthesis of GPI-anchored proteins	EGFR downregulation
Drugs
Diseases
GWAS		Adult body size ( 32376654) Aggressiveness in attention deficit hyperactivity disorder ( 27021288) Alzheimer's disease ( 33654092) Asperger disorder ( 21182207) Blood protein levels ( 30072576) Body size at age 10 ( 32376654) Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Familial lung adenocarcinoma ( 29924316) Feeling worry ( 29500382) Food addiction ( 27106561) Glucocorticoid-induced osteonecrosis (age 10 years and older) ( 26265699) Glucocorticoid-induced osteonecrosis (time dependent analysis) ( 26265699) Gut microbiota (functional units) ( 27694959) Intake of total sugars ( 31005972) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Male fertility ( 22633400) Mental health study participation (completed survey) ( 31263887) Myopia ( 27182965) Obesity-related traits ( 23251661) Plasma anti-thyroglobulin levels ( 29678681) Pre-treatment viral load in HIV-1 infection ( 31219150) Refractive error ( 32231278) Serum polyunsaturated fatty acid concentration x sex interaction in metabolic syndrome ( 31991592) Severe exacerbations in childhood asthma ( 33093117) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Sunburns ( 23548203)	Apolipoprotein B levels ( 32203549) Body shape index ( 34021172) Diastolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Irritable bowel syndrome ( 24797007) Itch intensity from mosquito bite adjusted by bite size ( 28199695) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Metabolite levels ( 23823483) Pelvic organ prolapse ( 26545240) Systolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Triglyceride levels ( 32203549)
Interacting Genes		20 interacting genes: APP C19orf47 CCKBR EFEMP2 KRTAP1-1 KRTAP3-2 KRTAP5-9 KRTAP9-3 LHB LINGO1 LSAMP MRPL12 NBPF19 NEGR1 NOTCH2NLA P4HB PAX4 QRFPR SPRY1 VWC2	85 interacting genes: ADAM12 ADAMTSL4 ANKRD11 ATXN7 CACNA1A CCDC57 CDR2L CHRD CREB5 CYSRT1 FARS2 FBLN1 FHL5 FXR1 FXR2 GEMIN4 GNE GRB2 GUCD1 HEXIM2 HOXA1 HRG HSF2BP INCA1 KPNA2 KPRP KRT31 KRTAP1-1 KRTAP1-3 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-2 KRTAP12-3 KRTAP3-2 KRTAP4-12 KRTAP4-2 KRTAP5-9 KRTAP9-2 KRTAP9-3 LCE1A LCE1B LCE1C LCE1D LCE1F LCE2A LCE2C LCE2D LCE3A LCE3C LCE3D LCE4A LCE5A MB21D2 MDFI MEOX2 NBPF19 NOTCH2NLA NTM OTX1 PCSK5 POLR1C PRKAA2 PRKAB2 R3HDM2 REL SMCP SOCS4 SPRY2 STAT3 TFAP2D TGM7 UBASH3A VWC2 YY1 ZNF23 ZNF330 ZNF417 ZNF441 ZNF837
Entrez ID		50863	10252
HPRD ID		06398	06782
Ensembl ID		ENSG00000182667	ENSG00000164056
Uniprot IDs		B7Z1I4 Q9P121	O43609
PDB IDs		6DLF
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?