PARD6A and GLS

Number of citations of the paper that reports this interaction (PubMedID 12629547)
122

Data Source:
HPRD (in vivo)

		PARD6A	GLS
Description		par-6 family cell polarity regulator alpha	glutaminase
Image
GO Annotations	Cellular Component	Ruffle Nucleus Centrosome Cytosol Plasma Membrane Bicellular Tight Junction Cell Cortex Apical Plasma Membrane Centriolar Satellite	Mitochondrion Mitochondrial Matrix Cytosol Synapse
	Molecular Function	Protein Kinase C Binding Protein Binding Transcription Factor Binding GTP-dependent Protein Binding Small GTPase Binding	Glutaminase Activity Protein Binding
	Biological Process	Negative Regulation Of Protein Phosphorylation Centrosome Cycle Establishment Or Maintenance Of Cell Polarity Viral Process Cell-cell Junction Maintenance Positive Regulation Of Protein Secretion Cell Division Regulation Of Cellular Localization Positive Regulation Of Protein Localization To Centrosome	Suckling Behavior Regulation Of Respiratory Gaseous Exchange By Nervous System Process Glutamate Biosynthetic Process Glutamine Catabolic Process Chemical Synaptic Transmission Protein Homotetramerization Glutamate Homeostasis
Pathways		TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) Tight junction interactions Asymmetric localization of PCP proteins CDC42 GTPase cycle RAC1 GTPase cycle RHOU GTPase cycle RHOV GTPase cycle	Glutamate Neurotransmitter Release Cycle TP53 Regulates Metabolic Genes Glutamate and glutamine metabolism
Drugs			Glutamic acid
Diseases
GWAS		Obesity-related traits ( 23251661) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)	Chronotype ( 30696823) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494 27863252) JT interval (sulfonylurea treatment interaction) ( 27958378) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		27 interacting genes: APP ATP5MG CDC42 CDH5 CRB3 DVL2 ECT2 GLS MAP2K5 MARK2 MARK4 PARD3 PARD6B PLCB1 PLCB3 PRKCG PRKCH PRKCI PRKCZ PTPN21 RAC1 RHOQ TCP10L3 TGFBR1 WDR83 YWHAH YWHAZ	7 interacting genes: ARL6 ATXN10 CDC42 OGT PARD6A SNTA1 TAX1BP3
Entrez ID		50855	2744
HPRD ID		06316	00700
Ensembl ID		ENSG00000102981	ENSG00000115419
Uniprot IDs		Q9NPB6	O94925 Q68D38
PDB IDs		1WMH	3CZD 3UNW 3UO9 3VOY 3VOZ 3VP0 3VP1 3VP2 3VP3 3VP4 4O7D 5D3O 5FI2 5FI6 5FI7 5HL1 5I94 5JYO 5JYP 5U0I 5U0J 5UQE 5WJ6 6LOX 6UJG 6UJM 6UK6 6UKB 6UL9 6ULA 6ULJ 6UMC 6UMD 6UME 6UMF
Enriched GO Terms of Interacting Partners?
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