SERPINB2 and PRPF8

Number of citations of the paper that reports this interaction (PubMedID 15346200)
3

Data Source:
BioGRID (two hybrid, affinity chromatography technology)
HPRD (in vivo, two hybrid)

		SERPINB2	PRPF8
Description		serpin family B member 2	pre-mRNA processing factor 8
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Plasma Membrane	Nucleus Nucleoplasm U5 SnRNP Membrane Nuclear Speck U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome U2-type Catalytic Step 1 Spliceosome U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity	RNA Binding Protein Binding Metallopeptidase Activity U6 SnRNA Binding U1 SnRNA Binding U2 SnRNA Binding U5 SnRNA Binding Isopeptidase Activity K63-linked Polyubiquitin Modification-dependent Protein Binding Pre-mRNA Intronic Binding
	Biological Process	Negative Regulation Of Endopeptidase Activity Wound Healing Fibrinolysis Negative Regulation Of Apoptotic Process	Spliceosomal Tri-snRNP Complex Assembly RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome MRNA Processing Proteolysis RNA Splicing Cellular Response To Lipopolysaccharide Cellular Response To Tumor Necrosis Factor
Pathways		Dissolution of Fibrin Clot Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway
Drugs		Urokinase Tenecteplase Lanoteplase
Diseases
GWAS		Asthma ( 31619474) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Hen's egg allergy ( 29051540) Hip circumference adjusted for BMI ( 28552196) Systolic blood pressure ( 29208002)	Blood protein levels ( 28240269) Calcium levels ( 20705733) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Ischemic stroke ( 29531354) Stroke ( 29531354)
Interacting Genes		9 interacting genes: APP CDC42 DCC IRF3 PLAU PRPF8 PSMB1 RB1 UBE3A	21 interacting genes: ABCA1 DHX9 DUX4 ERG GPKOW H2BC5 HNRNPH2 NEDD4 PIN1 PRPF19 PTEN RNF20 SERPINB2 SLC22A2 SMG6 SND1 SUMO2 TP53 UBC UBE2I ZNF830
Entrez ID		5055	10594
HPRD ID		01420	06295
Ensembl ID		ENSG00000197632	ENSG00000174231
Uniprot IDs		P05120	Q6P2Q9
PDB IDs		1BY7 1JRR 2ARQ 2ARR	3E9L 3ENB 3JCR 3LRU 4JK7 4JK8 4JK9 4JKA 4JKB 4JKC 4JKD 4JKE 4JKF 4JKG 4JKH 4KIT 5MQF 5O9Z 5XJC 5YZG 5Z56 5Z57 5Z58 6AH0 6AHD 6FF4 6FF7 6ICZ 6ID0 6ID1 6QDV 6QW6 6QX9 6S8Q 6S9I 6ZYM 7A5P 7AAV 7ABF 7ABG 7ABI
Enriched GO Terms of Interacting Partners?
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