P2RX1 and P2RX2

Number of citations of the paper that reports this interaction (PubMedID 15313628)
42

Data Source:
HPRD (in vitro)

		P2RX1	P2RX2
Description		purinergic receptor P2X 1	purinergic receptor P2X 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Integral Component Of Nuclear Inner Membrane Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Secretory Granule Membrane Protein-containing Complex Specific Granule Membrane Neuron Projection Membrane Raft Glutamatergic Synapse Integral Component Of Postsynaptic Membrane Integral Component Of Presynaptic Active Zone Membrane	Integral Component Of Nuclear Inner Membrane Plasma Membrane Integral Component Of Plasma Membrane Apical Plasma Membrane Neuronal Cell Body Receptor Complex Postsynapse
	Molecular Function	Purinergic Nucleotide Receptor Activity Extracellularly ATP-gated Cation Channel Activity Cation Channel Activity Protein Binding ATP Binding Identical Protein Binding Protein-containing Complex Binding	Purinergic Nucleotide Receptor Activity Extracellularly ATP-gated Cation Channel Activity ATP Binding Ligand-gated Ion Channel Activity Identical Protein Binding
	Biological Process	Serotonin Secretion By Platelet Regulation Of Vascular Associated Smooth Muscle Contraction Ion Transport Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Signal Transduction Insemination Regulation Of Blood Pressure Neuronal Action Potential Platelet Activation Response To ATP Synaptic Transmission, Glutamatergic Purinergic Nucleotide Receptor Signaling Pathway Ceramide Biosynthetic Process Excitatory Postsynaptic Potential Cation Transmembrane Transport Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Positive Regulation Of Calcium Ion Import Across Plasma Membrane Regulation Of Synaptic Vesicle Exocytosis	Response To Hypoxia Response To Ischemia Detection Of Hypoxic Conditions In Blood By Carotid Body Chemoreceptor Signaling Neuromuscular Synaptic Transmission Neuromuscular Junction Development Sensory Perception Of Sound Response To Carbohydrate Positive Regulation Of Calcium Ion Transport Into Cytosol Urinary Bladder Smooth Muscle Contraction Peristalsis Response To ATP Purinergic Nucleotide Receptor Signaling Pathway Behavioral Response To Pain Skeletal Muscle Fiber Development Positive Regulation Of Calcium-mediated Signaling Sensory Perception Of Taste Excitatory Postsynaptic Potential Cation Transmembrane Transport
Pathways		Elevation of cytosolic Ca2+ levels Platelet homeostasis Neutrophil degranulation	Elevation of cytosolic Ca2+ levels Platelet homeostasis
Drugs		Promethazine	Promethazine
Diseases
GWAS		Mean platelet volume ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494) Systemic sclerosis (anti-topoisomerase-positive) ( 29293537)	Body mass index ( 26426971) Fasting glucose ( 33402679)
Interacting Genes		2 interacting genes: CYBC1 P2RX2	3 interacting genes: GABRR1 P2RX1 P2RX3
Entrez ID		5023	22953
HPRD ID		07526	15984
Ensembl ID		ENSG00000108405	ENSG00000187848
Uniprot IDs		P51575	Q32MC3 Q9UBL9
PDB IDs
Enriched GO Terms of Interacting Partners?
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