OSM and COL4A6

Number of citations of the paper that reports this interaction (PubMedID 11711546)
13

Data Source:
BioGRID (imaging technique)
HPRD (in vitro)

		OSM	COL4A6
Description		oncostatin M	collagen type IV alpha 6 chain
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Collagen Type IV Trimer Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Collagen-containing Extracellular Matrix
	Molecular Function	Cytokine Activity Oncostatin-M Receptor Binding Protein Binding Growth Factor Activity	Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength
	Biological Process	Positive Regulation Of Acute Inflammatory Response Immune Response Multicellular Organism Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Interleukin-17 Production Positive Regulation Of Peptidyl-serine Phosphorylation Oncostatin-M-mediated Signaling Pathway Regulation Of Growth Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of MAPK Cascade Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Hormone Secretion Positive Regulation Of Inflammatory Response Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cell Division Positive Regulation Of Protein Kinase B Signaling Regulation Of Hematopoietic Stem Cell Differentiation	Cell Adhesion Extracellular Matrix Organization Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Cellular Response To Amino Acid Stimulus
Pathways		Interleukin-4 and Interleukin-13 signaling IL-6-type cytokine receptor ligand interactions	Collagen degradation Collagen degradation Extracellular matrix organization Collagen biosynthesis and modifying enzymes Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Integrin cell surface interactions Anchoring fibril formation Crosslinking of collagen fibrils Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans Collagen chain trimerization
Drugs
Diseases
GWAS		Coronary artery disease ( 29212778 33020668) Delirium ( 29631748) Heel bone mineral density ( 30598549) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Inflammatory bowel disease ( 23128233) Myocardial infarction ( 33532862) Nephropathy ( 21399633) Suicidal ideation ( 30145303) Tonsillectomy ( 27941131)	Electrodermal activity ( 25387706)
Interacting Genes		13 interacting genes: APP COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 IL6ST LIFR NF2 OSMR TNNT1 ZNF410	12 interacting genes: APP CD93 DCN FBLN2 FN1 HABP2 MAGEA6 MATN2 MMP9 NOTCH1 OSM SERPINE2
Entrez ID		5008	1288
HPRD ID		01300	02364
Ensembl ID		ENSG00000099985	ENSG00000197565
Uniprot IDs		B5MCX1 P13725	A0A087WZY5 A8MXH5 A8VPY0 B2RTX6 B7ZMM7 F5H3Q5 Q14031
PDB IDs		1EVS
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?