OPRK1 and OPRD1

Number of citations of the paper that reports this interaction (PubMedID 11069979)
160

Data Source:
HPRD (in vivo)

		OPRK1	OPRD1
Description		opioid receptor kappa 1	opioid receptor delta 1
Image
GO Annotations	Cellular Component	Nucleoplasm Cytosol Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Integral Component Of Synaptic Vesicle Membrane Dendrite Neuron Projection Perikaryon Axon Terminus Integral Component Of Postsynaptic Membrane Integral Component Of Presynaptic Membrane	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Synaptic Vesicle Membrane Intrinsic Component Of Plasma Membrane Dendrite Membrane Neuron Projection Axon Terminus Membrane Raft Spine Apparatus Neuronal Dense Core Vesicle Integral Component Of Presynaptic Membrane Integral Component Of Postsynaptic Density Membrane
	Molecular Function	G Protein-coupled Receptor Activity G Protein-coupled Opioid Receptor Activity Protein Binding Receptor Serine/threonine Kinase Binding Dynorphin Receptor Activity Peptide Binding Neuropeptide Binding	G Protein-coupled Receptor Activity G Protein-coupled Opioid Receptor Activity Protein Binding Receptor Serine/threonine Kinase Binding G Protein-coupled Enkephalin Receptor Activity Peptide Binding Neuropeptide Binding
	Biological Process	Immune Response Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Chemical Synaptic Transmission Sensory Perception Locomotory Behavior Response To Radiation Sensory Perception Of Pain Adenylate Cyclase-inhibiting Opioid Receptor Signaling Pathway Response To Insulin Positive Regulation Of Dopamine Secretion Negative Regulation Of Luteinizing Hormone Secretion G Protein-coupled Opioid Receptor Signaling Pathway Positive Regulation Of Locomotion Maternal Behavior Eating Behavior Response To Morphine Response To Estrogen Estrous Cycle Response To Ethanol Regulation Of Saliva Secretion Behavioral Response To Cocaine Sensory Perception Of Temperature Stimulus Defense Response To Virus Regulation Of Sensory Perception Of Pain Cellular Response To Lipopolysaccharide Cellular Response To Glucose Stimulus Positive Regulation Of P38MAPK Cascade Positive Regulation Of Potassium Ion Transmembrane Transport Response To Acrylamide Positive Regulation Of Eating Behavior Conditioned Place Preference	Immune Response G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Adult Locomotory Behavior Negative Regulation Of Gene Expression Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of CREB Transcription Factor Activity Positive Regulation Of Peptidyl-serine Phosphorylation G Protein-coupled Opioid Receptor Signaling Pathway Eating Behavior Regulation Of Mitochondrial Membrane Potential Regulation Of Calcium Ion Transport Regulation Of Sensory Perception Of Pain Cellular Response To Growth Factor Stimulus Cellular Response To Hypoxia Cellular Response To Toxic Substance
Pathways		Peptide ligand-binding receptors G alpha (i) signalling events MECP2 regulates neuronal receptors and channels	Peptide ligand-binding receptors G alpha (i) signalling events Interleukin-4 and Interleukin-13 signaling
Drugs		Tramadol Atomoxetine Morphine Codeine Amitriptyline Hydromorphone Mirtazapine Progesterone Meperidine Oxycodone Dextromethorphan Lamotrigine Butorphanol Dextropropoxyphene Pentazocine Naltrexone Sufentanil Fentanyl Levomenthol Loperamide Nalbuphine Levorphanol Remifentanil Buprenorphine Naloxone Dezocine Ketamine Aripiprazole 3-Methylthiofentanyl Diamorphine Etorphine Carfentanil Diprenorphine Dihydromorphine 3-Methylfentanyl V1003 Asimadoline CR665 ADL 10-0101 Mianserin Tapentadol Nalmefene Alvimopan Morphine glucuronide Ketobemidone Methylnaltrexone Butyrfentanyl Pholcodine Eluxadoline Opium Pentoxyverine Naldemedine Loxicodegol	Tramadol Morphine Codeine Amitriptyline Hydromorphone Methadone Oxycodone Dextromethorphan Butorphanol Dextropropoxyphene Naltrexone Sufentanil Fentanyl Loperamide Nalbuphine Levorphanol Remifentanil Buprenorphine Hydrocodone Diphenoxylate Naloxone Oxymorphone Ketamine Aripiprazole 3-Methylthiofentanyl Dimethylthiambutene Diamorphine Etorphine Carfentanil Diprenorphine Dihydromorphine 3-Methylfentanyl ADL5859 Tapentadol Nalmefene Alvimopan Morphine glucuronide Ketobemidone Cannabidiol Butyrfentanyl Pholcodine Eluxadoline Opium Naldemedine Metenkefalin Medical Cannabis Nabiximols Loxicodegol
Diseases
GWAS		Age at first sexual intercourse ( 34211149) Body size at age 10 ( 32376654) IgE levels in asthmatics (D.p. specific) ( 23967269) Modic changes ( 30808802) Systolic blood pressure x quantitative lifestyle risk score interaction (2df test) ( 32227373)	Tourette syndrome ( 30818990)
Interacting Genes		6 interacting genes: GABARAPL1 GNA15 GPRASP1 NKG7 OPRD1 SLC9A3R1	22 interacting genes: ADRB2 ARRB1 ARRB2 CTXN3 GNA15 GNAI1 GNAI2 GNAO1 GNAZ GPRASP1 GRK2 KLHL3 OPRK1 OPRM1 PRKCA PRKCD PRKCE RPRM SLC12A7 SLC13A4 SMAGP TMEM237
Entrez ID		4986	4985
HPRD ID		01309	01308
Ensembl ID		ENSG00000082556	ENSG00000116329
Uniprot IDs		A0A5F9ZI09 P41145	P41143
PDB IDs		2A0D 2IQN 4DJH 6B73 6VI4	1OZC 2IQM 4N6H 4RWA 4RWD 6PT2 6PT3
Enriched GO Terms of Interacting Partners?
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