NPPB and NPR3

Number of citations of the paper that reports this interaction (PubMedID 1672777)
90

Data Source:
BioGRID (pull down, x-ray crystallography)
HPRD (in vitro, in vivo)

		NPPB	NPR3
Description		natriuretic peptide B	natriuretic peptide receptor 3
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Protein-containing Complex	Integral Component Of Plasma Membrane Protein-containing Complex Extracellular Exosome
	Molecular Function	Signaling Receptor Binding Hormone Activity Protein Binding Diuretic Hormone Activity Hormone Receptor Binding	Protein Binding G Protein-coupled Peptide Receptor Activity Natriuretic Peptide Receptor Activity Peptide Hormone Binding Chloride Ion Binding Peptide Binding Hormone Binding Protein Homodimerization Activity
	Biological Process	Negative Regulation Of Systemic Arterial Blood Pressure Cardiac Conduction System Development CGMP Biosynthetic Process Protein Folding Cell Surface Receptor Signaling Pathway Receptor Guanylyl Cyclase Signaling Pathway Neuropeptide Signaling Pathway Body Fluid Secretion Regulation Of Blood Pressure Negative Regulation Of Angiogenesis CGMP-mediated Signaling Negative Regulation Of Cell Growth Positive Regulation Of Urine Volume Positive Regulation Of Renal Sodium Excretion Vasodilation Regulation Of Vascular Permeability Blood Vessel Diameter Maintenance	Skeletal System Development Osteoclast Proliferation Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Blood Pressure Pancreatic Juice Secretion Regulation Of Osteoblast Proliferation Positive Regulation Of Urine Volume Vasodilation Phosphatidylinositol-mediated Signaling Negative Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Nitric-oxide Synthase Activity Negative Regulation Of Cold-induced Thermogenesis
Pathways
Drugs		Carvedilol Oxymetholone	Nesiritide
Diseases
GWAS		B-type natriuretic peptide levels ( 29237677 25561047) B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio ( 29237677) Blood pressure ( 21909110) Blood protein levels ( 30072576 29875488) Blood protein levels in cardiovascular risk ( 28369058) Diastolic blood pressure ( 28739976 27618452) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Hip index ( 34021172) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) N-terminal pro B-type natriuretic peptide levels ( 29237677) NT-proBNP levels in acute coronary syndrome ( 26908625) Pulse pressure ( 30578418) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure ( 19430483 28739976 27618447 27618452) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Tuberculosis ( 29036319)	Blood pressure ( 24954895 21572416 21909110) Diastolic blood pressure ( 26390057 27841878 21909115 28739976 27618452) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Height ( 28552196 20881960 25282103 19343178 23563607 31562340 28270201 19570815) Hip circumference adjusted for BMI ( 34021172 25673412) Hypertension ( 31879980 21909115) Mean arterial pressure ( 26390057 29403010 30487518) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Ovarian reserve ( 22116950) Pulse pressure ( 27841878 28739976 30578418) Pulse pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Symptoms in placebo-treated COVID-19 outpatients at risk of severe disease (time to remission) ( 34035401) Systolic blood pressure ( 26390057 28135244 27841878 21909115 29403010 28739976 27618447 27618452 30578418) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 34021172 28448500) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		17 interacting genes: CYSRT1 EWSR1 GEMIN4 HDAC4 KRT40 KRTAP10-3 KRTAP10-9 MTOR NOTCH2NLA NPR1 NPR2 NPR3 PSMA3 SERTAD3 SLC45A1 SMARCA4 TNFRSF25	6 interacting genes: NFKBIE NPPA NPPB NPPC NSD1 SLC30A9
Entrez ID		4879	4883
HPRD ID		08974	00167
Ensembl ID		ENSG00000120937	ENSG00000113389
Uniprot IDs		P16860	A8K4A5 P17342 Q60I31
PDB IDs		1YK1 3N56	1JDN 1JDP 1YK0 1YK1
Enriched GO Terms of Interacting Partners?
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