NNMT and BIRC5

		NNMT	BIRC5
Description		nicotinamide N-methyltransferase	baculoviral IAP repeat containing 5
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GO Annotations	Cellular Component	Cytosol	Nuclear Chromosome Chromosome, Centromeric Region Kinetochore Nucleus Nucleoplasm Cytoplasm Cytosol Spindle Microtubule Midbody Chromosome Passenger Complex
	Molecular Function	Nicotinamide N-methyltransferase Activity N-methyltransferase Activity Pyridine N-methyltransferase Activity	Protein Binding Microtubule Binding Enzyme Binding Small GTPase Binding Identical Protein Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Metal Ion Binding Chaperone Binding
	Biological Process	Nicotinamide Metabolic Process Response To Xenobiotic Stimulus Response To Organonitrogen Compound Regulation Of Polyamine Biosynthetic Process Regulation Of Histone Methylation Animal Organ Regeneration Methylation NAD Biosynthesis Via Nicotinamide Riboside Salvage Pathway Positive Regulation Of Gluconeogenesis Regulation Of Histone H3-K4 Methylation Positive Regulation Of Protein Deacetylation	Protein Phosphorylation Apoptotic Process Cell Cycle Chromosome Segregation Sensory Perception Of Sound Positive Regulation Of Cell Population Proliferation Protein-containing Complex Localization Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Transcription, DNA-templated Cell Division Regulation Of Cell Cycle
Pathways		Methylation Nicotinamide salvaging Metabolism of ingested SeMet, Sec, MeSec into H2Se	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion SUMOylation of DNA replication proteins RHO GTPases Activate Formins Interleukin-4 and Interleukin-13 signaling TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain Mitotic Prometaphase Neddylation EML4 and NUDC in mitotic spindle formation
Drugs		Niacin	Reserpine Berberine LY2181308
Diseases
GWAS		Asthma ( 29273806) Diisocyanate-induced asthma ( 25918132) Volumetric brain MRI ( 17903297)	Blood trace element (Se levels) ( 23720494) Periodontitis (Mean PAL) ( 24024966)
Interacting Genes		4 interacting genes: APP ATF6 BIRC5 BMF	34 interacting genes: AANAT AKAP6 AURKA AURKB AURKC BIRC2 BIRC3 BIRC6 CASP3 CASP7 CASP9 CCDC85B CDCA8 CDK1 CDK4 CSNK1D DIABLO EVI5 FASN FBXL7 GCGR H3-4 H3C14 HSP90AA1 INCENP KCNJ6 NNMT OGT RAN RASA1 SSH2 TLE3 XIAP XPO1
Entrez ID		4837	332
HPRD ID		02478	04520
Ensembl ID		ENSG00000166741	ENSG00000089685
Uniprot IDs		P40261 Q6FH49	A0A0B4J1S3 H3BLT4 O15392
PDB IDs		2IIP 3ROD 5YJF 6B1A 6CHH 6ORR 6PVE 6PVS	1E31 1F3H 1XOX 2QFA 2RAW 2RAX 3UEC 3UED 3UEE 3UEF 3UEG 3UEH 3UEI 3UIG 3UIH 3UII 3UIJ 3UIK 4A0I 4A0J 4A0N 6SHO 6YIE 6YIF 6YIH
Enriched GO Terms of Interacting Partners?
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