NKX3-1 and SLC22A18

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		NKX3-1	SLC22A18
Description		NK3 homeobox 1	solute carrier family 22 member 18
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytosol Site Of DNA Damage	Nuclear Envelope Cytoplasm Plasma Membrane Membrane Integral Component Of Membrane Apical Plasma Membrane
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Estrogen Receptor Binding Histone Deacetylase Binding Sequence-specific DNA Binding Protein Self-association MADS Box Domain Binding DNA-binding Transcription Factor Binding Transcription Regulator Inhibitor Activity Sequence-specific Double-stranded DNA Binding	Protein Binding Symporter Activity Solute:proton Antiporter Activity Transmembrane Transporter Activity Ubiquitin Protein Ligase Binding
	Biological Process	Metanephros Development Somitogenesis Positive Regulation Of Protein Phosphorylation Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Multicellular Organism Development Salivary Gland Development Heart Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Male Gonad Development Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Cell Death Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Cell Differentiation Androgen Receptor Signaling Pathway Regulation Of Protein Localization Response To Testosterone Dorsal Aorta Development Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Protein Kinase B Signaling Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Branching Morphogenesis Of An Epithelial Tube Negative Regulation Of Epithelial Cell Proliferation Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Cell Cycle Positive Regulation Of Cell Division Pharyngeal System Development Branching Involved In Prostate Gland Morphogenesis Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Steroid Hormone Stimulus Cellular Response To Hypoxia Positive Regulation Of Androgen Secretion Positive Regulation Of Response To DNA Damage Stimulus Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Excretion Organic Cation Transport Xenobiotic Transport Proton Transmembrane Transport Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane
Pathways			Organic cation transport Defective SLC22A18 causes lung cancer (LNCR) and embryonal rhabdomyosarcoma 1 (RMSE1)
Drugs
Diseases
GWAS		Birth weight ( 31043758) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular hemoglobin concentration ( 29403010) Prostate cancer ( 32986714 34012061 26443449) Prostate-specific antigen levels ( 28139693) Waist-hip ratio ( 25673412) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Apolipoprotein A1 levels ( 32203549) Bilirubin levels ( 19414484) Calcium levels ( 20705733) HDL cholesterol levels ( 32203549) High density lipoprotein cholesterol levels ( 29083408) Malaria ( 31844061) Total bilirubin levels ( 29403010)
Interacting Genes		37 interacting genes: AEN CCT7 CD200R1L CENPX CHPF CKAP4 FEM1B HIPK2 HMG20B HNRNPA0 HSP90B1 LMCD1 MAN2B1 MNAT1 MT-ND4 PEBP1 PTMS RABL6 RARG RHOXF2 RNF4 RPL37A RPSA SLC22A18 SP1 SP2 SP3 SP4 SP5 SPDEF SRF STMN3 TEX264 TOPORS TPT1 WDR77 ZNF417	6 interacting genes: HSD17B11 NKX3-1 RNF167 RRM1 TLCD4 TMX2
Entrez ID		4824	5002
HPRD ID		03620	04024
Ensembl ID		ENSG00000167034	ENSG00000110628
Uniprot IDs		Q99801	E9PRM7 Q96BI1
PDB IDs		2L9R
Enriched GO Terms of Interacting Partners?
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