NFKBIA and IKBKE

Number of citations of the paper that reports this interaction (PubMedID 10421793)
115

Data Source:
HPRD (in vitro)

		NFKBIA	IKBKE
Description		NFKB inhibitor alpha	inhibitor of nuclear factor kappa B kinase subunit epsilon
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane I-kappaB/NF-kappaB Complex	Nucleus Nucleoplasm Cytoplasm Cytosol PML Body Mitochondrial Membrane
	Molecular Function	Protein Binding Transcription Factor Binding Nuclear Localization Sequence Binding Enzyme Binding Ubiquitin Protein Ligase Binding Identical Protein Binding NF-kappaB Binding	Protein Serine/threonine Kinase Activity NF-kappaB-inducing Kinase Activity Protein Binding ATP Binding IkappaB Kinase Activity Protein Phosphatase Binding Ubiquitin Protein Ligase Binding K48-linked Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding K63-linked Polyubiquitin Modification-dependent Protein Binding
	Biological Process	Protein Import Into Nucleus Apoptotic Process I-kappaB Kinase/NF-kappaB Signaling Cytoplasmic Sequestering Of NF-kappaB Negative Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Cholesterol Efflux Negative Regulation Of Lipid Storage Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Cellular Protein Metabolic Process Response To Muramyl Dipeptide Tumor Necrosis Factor-mediated Signaling Pathway Toll-like Receptor 4 Signaling Pathway Response To Muscle Stretch Regulation Of Cell Population Proliferation Cytoplasmic Sequestering Of Transcription Factor Response To Exogenous DsRNA Negative Regulation Of DNA Binding Negative Regulation Of Myeloid Cell Differentiation Negative Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Inflammatory Response Cellular Response To Cold Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Regulation Of NIK/NF-kappaB Signaling	Protein Phosphorylation Immune Response I-kappaB Phosphorylation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Gene Expression Positive Regulation Of Lipid Storage Peptidyl-serine Phosphorylation Response To Type I Interferon Response To Interferon-beta NIK/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Protein-containing Complex Assembly MRNA Stabilization Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Type I Interferon-mediated Signaling Pathway Interleukin-17-mediated Signaling Pathway Cellular Response To Virus
Pathways		Activation of NF-kappaB in B cells RIP-mediated NFkB activation via ZBP1 Downstream TCR signaling NF-kB is activated and signals survival FCERI mediated NF-kB activation TAK1 activates NFkB by phosphorylation and activation of IKKs complex SUMOylation of immune response proteins IkBA variant leads to EDA-ID CLEC7A (Dectin-1) signaling Ub-specific processing proteases Interleukin-1 signaling TRAF6 mediated NF-kB activation	SUMOylation of immune response proteins TICAM1-dependent activation of IRF3/IRF7 TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation Negative regulators of DDX58/IFIH1 signaling Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
Drugs		Acetylsalicylic acid Bardoxolone methyl Astaxanthin	Fostamatinib
Diseases
GWAS		Asthma ( 30929738 32296059) Asthma (childhood onset) ( 30929738) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Creatine kinase levels ( 29403010) Eczema ( 31361310) Hip circumference adjusted for BMI ( 25673412) Inflammatory skin disease ( 25574825) Lymphocyte counts ( 32888494 27863252) PR interval ( 32439900) Psoriasis ( 25854761 25903422 20953189 20953190 25574825 23143594) Psoriasis vulgaris ( 26626624) Pulse pressure ( 27841878 30578418) Rheumatoid arthritis ( 32723749) Systolic blood pressure ( 27841878 28739976 30578418) White blood cell count ( 32888494)	Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Metabolite levels ( 23823483) Psoriasis ( 28537254) Systemic lupus erythematosus ( 27399966 33272962)
Interacting Genes		90 interacting genes: ABL1 ARRB1 ARRB2 ATF4 AURKA BARD1 BTRC CAPN1 CAPN2 CD7 CDC34 CHUK COMMD1 COPS8 CSNK2A1 CUL1 DNAJA3 DYNLL1 EIF2AK2 ELOC ELP1 ENKD1 FBXW11 G3BP2 HDAC1 HDAC3 HNRNPA1 HOXA9 HOXB7 HSPB1 IKBKB IKBKE IKBKG IKZF4 ITPK1 JAK2 LCK LYL1 MAP3K1 MAP3K14 MAP3K2 MAP3K3 MAP3K7 MCM5 MCM7 MED19 NCOR2 NEDD9 NFKB1 NFKB2 NFKBIB NKIRAS1 NKIRAS2 PIK3R1 PIR POLR2C POM121 PRKCA PRKCI PSMA2 PSMD3 PTPN1 PTPN13 REL RELA RNF115 RPS6KA1 RPS6KA3 RWDD3 SKP1 SLC25A4 SLC25A5 SRC ST7 SUMO1 SUMO4 TBK1 TCL1A TNF TNFSF11 TP53 TUBA1B UBE2D1 UBE2D2 UBE2D3 UBE2E3 UBE2I UBE2L3 VCP ZNF212	26 interacting genes: AZI2 BIRC2 BIRC3 CDC37 CHUK CSF2 CYLD DAXX DDX3X FKBP5 HSP90AA1 HSP90AB1 IRF3 IRF5 KTN1 MBP MUC1 NFKBIA PTGFR RELA RIPK1 SIKE1 TANK TICAM1 TRIM27 XIAP
Entrez ID		4792	9641
HPRD ID		01235	05442
Ensembl ID		ENSG00000100906	ENSG00000263528
Uniprot IDs		P25963	A0A075B7B4 Q14164
PDB IDs		1IKN 1NFI 6TTU 6Y1J
Enriched GO Terms of Interacting Partners?
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