NFATC2 and NFATC2IP

Number of citations of the paper that reports this interaction (PubMedID 8943202)
24

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		NFATC2	NFATC2IP
Description		nuclear factor of activated T cells 2	nuclear factor of activated T cells 2 interacting protein
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol Ribonucleoprotein Complex	Nucleus Cytoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Phosphatase Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cytokine Production Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Cellular Response To DNA Damage Stimulus Response To Xenobiotic Stimulus Positive Regulation Of Gene Expression Myotube Cell Development Cell Migration Positive Regulation Of B Cell Proliferation Calcineurin-NFAT Signaling Cascade Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II B Cell Receptor Signaling Pathway Positive Regulation Of Myoblast Fusion Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation	Cytokine Production Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Calcineurin activates NFAT Calcineurin activates NFAT FCERI mediated Ca+2 mobilization CLEC7A (Dectin-1) induces NFAT activation RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Asparaginase hypersensitivity in acute lymphoblastic leukemia ( 25987655) Asthma ( 32296059) Body shape index ( 34021172) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494 27863252) Height ( 28552196) Lymphocyte counts ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Molar-incisor hypomineralization ( 23918034) Self-reported allergy ( 23817569) Sitting height ratio ( 25865494) Sum eosinophil basophil counts ( 27863252) Systolic blood pressure ( 30224653) Tourette's syndrome or obsessive-compulsive disorder ( 25158072) Type 2 diabetes ( 32499647 30718926) Urinary uric acid excretion ( 31993563) Weight ( 28552196) White matter microstructure in first episode schizophrenia (right anterior cingulate cortex) ( 28924203)	Educational attainment ( 25201988) Non-albumin protein levels ( 29403010)
Interacting Genes		19 interacting genes: CREBBP EGR1 EGR4 EP300 FOXP3 IRF2BP2 IRF4 MED31 MEF2D NFATC2IP PIN1 PPP3CB PPP3R1 PRKCZ SNIP1 TAF9 VIM YWHAQ YWHAZ	9 interacting genes: BATF3 C22orf39 CCDC157 DNAL4 KAT8 NFATC2 NMNAT1 SUMO2 ZDHHC17
Entrez ID		4773	84901
HPRD ID		02730	10971
Ensembl ID		ENSG00000101096	ENSG00000176953
Uniprot IDs		B5B2P4 Q13469	Q8NCF5
PDB IDs		1A02 1OWR 1P7H 1PZU 1S9K 2AS5 2O93 3QRF	2JXX 2L76 3RD2
Enriched GO Terms of Interacting Partners?
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