NF2 and SOX3

Number of citations of the paper that reports this interaction (PubMedID 28205554)
52

Data Source:
BioGRID (fluorescent resonance energy transfer)

		NF2	SOX3
Description		neurofibromin 2	SRY-box transcription factor 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Early Endosome Cytosol Cytoskeleton Plasma Membrane Adherens Junction Membrane Lamellipodium Cortical Actin Cytoskeleton Filopodium Membrane Cleavage Furrow Ruffle Membrane Neuron Projection Cell Body Apical Part Of Cell Perinuclear Region Of Cytoplasm	Chromatin Nucleoplasm
	Molecular Function	Actin Binding Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Mesoderm Formation Negative Regulation Of Cell-matrix Adhesion Negative Regulation Of Protein Kinase Activity Ectoderm Development Negative Regulation Of Cell Population Proliferation Schwann Cell Proliferation Regulation Of Gliogenesis Hippocampus Development Negative Regulation Of Cell-cell Adhesion Actin Cytoskeleton Organization Negative Regulation Of Cell Migration Regulation Of Protein Stability Regulation Of Hippo Signaling Odontogenesis Of Dentin-containing Tooth Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Apoptotic Process Negative Regulation Of MAPK Cascade Cell-cell Junction Organization Positive Regulation Of Cell Differentiation Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Stress Fiber Assembly Regulation Of Cell Cycle Lens Fiber Cell Differentiation Regulation Of Stem Cell Proliferation Regulation Of Protein Localization To Nucleus Regulation Of Neural Precursor Cell Proliferation	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Central Nervous System Development Sensory Organ Development Sex Determination Anatomical Structure Morphogenesis Hypothalamus Development Pituitary Gland Development Cell Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Face Development
Pathways		Regulation of actin dynamics for phagocytic cup formation RHO GTPases activate PAKs	Deactivation of the beta-catenin transactivating complex
Drugs
Diseases
GWAS		Carotid atherosclerosis in HIV infection ( 20009918)	Height ( 31562340)
Interacting Genes		75 interacting genes: AGAP2 AKT1 AMOTL2 ARAF ARNT AURKA BDKRB1 BECN1 BYSL CBLC CCNB1IP1 CCND2 CCNE1 CD44 CDK4 CDK6 CDKN2B CDKN2C CTNNB1 DACH1 DCAF1 DRG1 EGFR EIF3B EMD EPHA2 ERBB2 EZR FGFR4 FZR1 GLIS2 GRM1 HGF HGS HIF1A IGF1R ITGB1 KAT2A KDELR2 LATS2 LIF MAP2K3 MAP2K5 MAP3K5 MAPK14 MDM4 MED28 MET MYBPC2 MYC OSM PAK1 PCNA PDGFRA PRKCA PXN PYGO2 RAF1 RALGDS RASSF1 SCHIP1 SDCBP SGSM3 SLC9A3R1 SOX3 SOX4 SPTBN1 STK11 TARBP2 TERT TP53 TSC1 TTYH2 TXLNB XPO1	14 interacting genes: ATXN1 AURKA CDKN2A CRX DACH1 GLIS1 GLIS2 MYC NF2 NFIC NSD3 PAX6 TEAD2 TERT
Entrez ID		4771	6658
HPRD ID		06980	02432
Ensembl ID		ENSG00000186575	ENSG00000134595
Uniprot IDs		A0A024R1D9 A0A024R1F6 A0A024R1I0 A0A024R1J8 A0A024R1J9 P35240	P41225
PDB IDs		1H4R 3U8Z 4ZRI 4ZRJ 6CDS
Enriched GO Terms of Interacting Partners?
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