ACLY and KLHL25

Number of citations of the paper that reports this interaction (PubMedID 27664236)
20

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		ACLY	KLHL25
Description		ATP citrate lyase	kelch like family member 25
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleoplasm Cytosol Plasma Membrane Membrane Azurophil Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen	Cytoplasm Cytosol Cul3-RING Ubiquitin Ligase Complex
	Molecular Function	ATP Citrate Synthase Activity Protein Binding ATP Binding Metal Ion Binding
	Biological Process	Acetyl-CoA Biosynthetic Process Citrate Metabolic Process Oxaloacetate Metabolic Process Fatty Acid Biosynthetic Process Cholesterol Biosynthetic Process Lipid Biosynthetic Process Coenzyme A Metabolic Process	Regulation Of Translational Initiation Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination
Pathways		ChREBP activates metabolic gene expression Neutrophil degranulation Fatty acyl-CoA biosynthesis	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Bempedoic acid
Diseases
GWAS		High light scatter reticulocyte percentage of red cells ( 27863252)	Adverse response to chemotherapy in breast cancer (alopecia) (anti-microtubule) ( 24025145) Adverse response to chemotherapy in breast cancer (alopecia) (docetaxel) ( 24025145) Aging traits ( 17903295) Birth weight ( 31043758) Idiopathic pulmonary fibrosis ( 29066090) Offspring birth weight ( 31043758) Psychosis (methamphetamine induced) ( 23594818) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355)
Interacting Genes		9 interacting genes: APP CDKN2A CUL3 DDIAS FXR1 GSK3B HGS KLHL25 PRKACA	2 interacting genes: ACLY SEC11A
Entrez ID		47	64410
HPRD ID		00155	07780
Ensembl ID		ENSG00000131473	ENSG00000183655
Uniprot IDs		A0A024R1T9 A0A024R1Y2 P53396 Q4LE36	Q9H0H3
PDB IDs		3MWD 3MWE 3PFF 5TDE 5TDF 5TDM 5TDZ 5TE1 5TEQ 5TES 5TET 6HXH 6HXK 6HXL 6HXM 6O0H 6POE 6POF 6QFB 6UI9 6UIA 6UUW 6UUZ 6UV5 7LLA
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?