MTRR and MMAB

Number of citations of the paper that reports this interaction (PubMedID 15347655)
27

Data Source:
HPRD (in vitro)

		MTRR	MMAB
Description		5-methyltetrahydrofolate-homocysteine methyltransferase reductase	metabolism of cobalamin associated B
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GO Annotations	Cellular Component	Nucleoplasm Cytosol Intermediate Filament Cytoskeleton	Mitochondrial Matrix
	Molecular Function	NADPH-hemoprotein Reductase Activity Protein Binding FMN Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Metal Ions, NAD Or NADP As Acceptor [methionine Synthase] Reductase Activity Flavin Adenine Dinucleotide Binding NADPH Binding FAD Binding	Protein Binding ATP Binding Cob(I)yrinic Acid A,c-diamide Adenosyltransferase Activity Cobalamin Binding
	Biological Process	DNA Methylation Methionine Biosynthetic Process S-adenosylmethionine Cycle Homocysteine Catabolic Process Folic Acid Metabolic Process Homocysteine Metabolic Process Negative Regulation Of Cystathionine Beta-synthase Activity	Cobalamin Metabolic Process
Pathways		Methylation Sulfur amino acid metabolism Cobalamin (Cbl, vitamin B12) transport and metabolism Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective MTR causes methylmalonic aciduria and homocystinuria type cblG	Cobalamin (Cbl, vitamin B12) transport and metabolism Defective MMAB causes methylmalonic aciduria type cblB
Drugs		Cyanocobalamin Methionine
Diseases
GWAS		Capecitabine sensitivity ( 22864933) Hyperinsulinemia in lower physical activity ( 30327367) Metabolite levels ( 23823483) Verbal declarative memory ( 25648963)	Age-related nuclear cataracts ( 33311586 24951543) Apolipoprotein A1 levels ( 32203549) Fish- and plant-related diet ( 32066663) HDL cholesterol ( 18193043 20864672 19060906 25961943 20686565) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) High density lipoprotein cholesterol levels ( 33339817) Monocyte percentage of white cells ( 32888494) Non-oily fish consumption ( 32066663) Oily fish consumption ( 32066663) Polymyositis ( 26362759) Pork consumption ( 32066663) Red cell distribution width ( 32888494)
Interacting Genes		3 interacting genes: GFER GMCL1 MMAB	2 interacting genes: CBY2 MTRR
Entrez ID		4552	326625
HPRD ID		03979	07398
Ensembl ID		ENSG00000124275	ENSG00000139428
Uniprot IDs		Q9UBK8	Q96EY8
PDB IDs		2QTL 2QTZ	2IDX 6D5K 6D5X
Enriched GO Terms of Interacting Partners?
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