MTTP and HSP90B1

Number of citations of the paper that reports this interaction (PubMedID 9694898)
21

Data Source:
HPRD (in vivo)

		MTTP	HSP90B1
Description		microsomal triglyceride transfer protein	heat shock protein 90 beta family member 1
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Rough Endoplasmic Reticulum Golgi Apparatus Basolateral Plasma Membrane Brush Border Membrane Microvillus Membrane Vesicle Receptor Complex	Extracellular Region Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Focal Adhesion Membrane Midbody Protein-containing Complex Sarcoplasmic Reticulum Lumen Endoplasmic Reticulum Chaperone Complex Melanosome Perinuclear Region Of Cytoplasm Collagen-containing Extracellular Matrix Extracellular Exosome Endocytic Vesicle Lumen
	Molecular Function	Lipid Transporter Activity Protein Binding Phospholipid Transporter Activity Lipid Binding Apolipoprotein Binding Protein-containing Complex Binding Protein Heterodimerization Activity Phospholipid Transfer Activity Phosphatidylcholine Transfer Activity Cholesterol Transfer Activity Triglyceride Transfer Activity Ceramide 1-phosphate Transfer Activity Phosphatidylethanolamine Transfer Activity	RNA Binding Calcium Ion Binding Protein Binding ATP Binding Protein Phosphatase Binding Low-density Lipoprotein Particle Receptor Binding Unfolded Protein Binding
	Biological Process	Protein Lipidation Lipid Metabolic Process Triglyceride Metabolic Process Circadian Rhythm Protein Secretion Phospholipid Transport Sterol Transport Triglyceride Transport Low-density Lipoprotein Particle Remodeling Plasma Lipoprotein Particle Assembly Chylomicron Assembly Very-low-density Lipoprotein Particle Assembly Lipoprotein Metabolic Process Cholesterol Homeostasis Lipoprotein Transport Response To Calcium Ion Intermembrane Lipid Transfer Ceramide 1-phosphate Transport	Response To Hypoxia Protein Folding Protein Transport Ubiquitin-dependent ERAD Pathway Retrograde Protein Transport, ER To Cytosol Actin Rod Assembly Protein Folding In Endoplasmic Reticulum Response To Endoplasmic Reticulum Stress Negative Regulation Of Apoptotic Process Regulation Of Phosphoprotein Phosphatase Activity Sequestering Of Calcium Ion Cellular Response To ATP
Pathways		VLDL assembly Chylomicron assembly	Trafficking and processing of endosomal TLR Scavenging by Class A Receptors Scavenging by Class A Receptors ATF6 (ATF6-alpha) activates chaperone genes Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Interleukin-4 and Interleukin-13 signaling Post-translational protein phosphorylation
Drugs		Hesperetin Implitapide SLx-4090 Lomitapide	Rifabutin 2-Chlorodideoxyadenosine Geldanamycin Diglyme N-Ethyl-5'-Carboxamido Adenosine Radicicol METHYL 3-CHLORO-2-{3-[(2,5-DIHYDROXY-4-METHOXYPHENYL)AMINO]-3-OXOPROPYL}-4,6-DIHYDROXYBENZOATE 2-(3-AMINO-2,5,6-TRIMETHOXYPHENYL)ETHYL 5-CHLORO-2,4-DIHYDROXYBENZOATE Copper
Diseases
GWAS		Alanine aminotransferase levels ( 34315874) Aspartate aminotransferase levels ( 34315874) Celiac disease ( 23936387) HDL cholesterol ( 30275531) Liver enzyme levels (alanine transaminase) ( 33972514) Percent liver fat ( 34128465) Regular attendance at a pub or social club ( 29970889) Triglyceride levels ( 32203549)	Blood protein levels ( 29875488) Metabolite levels ( 23823483) Soluble VCAM-1 levels ( 31217265)
Interacting Genes		3 interacting genes: APOB HSP90B1 TYK2	39 interacting genes: APOB ASGR1 BIRC2 CACYBP CAMLG CCT2 CSNK2A1 CSNK2A2 CYSLTR2 EGFR EPB41L4B ERBB2 ESR1 FANCC GPR37 HSPA9 LINC01554 LRP1 MAPK6 MDM2 MMP17 MTTP NKX3-1 OGT OS9 POLR2E PTEN PTPN11 RXFP3 SGTB SIRPA SUPT6H TG TLR1 TLR2 TLR4 TP53 TXNDC11 UBASH3A
Entrez ID		4547	7184
HPRD ID		01144	01860
Ensembl ID		ENSG00000138823	ENSG00000166598
Uniprot IDs		B7Z7X3 E9PBP6 P55157	P14625 V9HWP2
PDB IDs			4NH9
Enriched GO Terms of Interacting Partners?
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