MT2A and RIN3

Number of citations of the paper that reports this interaction (PubMedID 25814554)
26

Data Source:
BioGRID (two hybrid)

		MT2A	RIN3
Description		metallothionein 2A	Ras and Rab interactor 3
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Cytoplasm Early Endosome Cytosol Endocytic Vesicle Axon Dendrite Cytoplasmic Vesicle Vesicle Neuronal Cell Body
	Molecular Function	Protein Binding Zinc Ion Binding Metal Ion Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding Small GTPase Binding
	Biological Process	Cellular Copper Ion Homeostasis Cellular Zinc Ion Homeostasis Detoxification Of Copper Ion Cellular Response To Interleukin-3 Cellular Response To Erythropoietin Negative Regulation Of Growth Cellular Response To Cadmium Ion Cellular Response To Copper Ion Cellular Response To Zinc Ion	Negative Regulation Of Receptor Internalization Endocytosis Signal Transduction Regulation Of Catalytic Activity Negative Regulation Of Mast Cell Chemotaxis Regulation Of Vesicle Size
Pathways		Metallothioneins bind metals Metallothioneins bind metals Interferon gamma signaling	RAB GEFs exchange GTP for GDP on RABs
Drugs		Zinc Silver Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS			Alzheimer's disease ( 31473137) Alzheimer's disease (late onset) ( 30617256 24162737) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Appendicular lean mass ( 33097823) Asthma ( 32296059) Bone mineral density (paediatric, lower limb) ( 24945404) Bone mineral density (paediatric, total body less head) ( 24945404) Breast cancer ( 25751625 29059683) Childhood ALL/LBL (acute lymphoblastic leukemia/lymphoblastic lymphoma) treatment-related venous thromboembolism ( 32438682) Chronic obstructive pulmonary disease ( 28166215 30804561 25101718 33909500) Chronic obstructive pulmonary disease (moderate to severe) ( 24621683) Chronic obstructive pulmonary disease (severe) ( 24621683) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Composite immunoglobulin trait (IgA/IgM) ( 28628107) Dialysis-related mortality ( 21546767) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of white cells ( 32888494) Estimated glomerular filtration rate ( 31152163) FEV1 ( 30804560) Granulocyte count ( 27863252) Hip index ( 34021172) Local histogram emphysema pattern ( 25006744) Lung function (FEV1) ( 26635082) Lung function (FVC) ( 26635082 30804560) Lymphocyte percentage of white cells ( 32888494 27863252) Mean platelet volume ( 32888494) Monocyte count ( 32888494 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494) Paget's disease ( 21623375) Platelet distribution width ( 32888494) Plateletcrit ( 32888494 27863252) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Proximal colorectal cancer ( 33632709) Pulse pressure ( 30224653) Sepsis (28-day mortality) ( 32592749) Serum alkaline phosphatase levels ( 33547301) Sum basophil neutrophil counts ( 27863252) Sum eosinophil basophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systemic juvenile idiopathic arthritis ( 27927641) White blood cell count ( 32888494 27863252)
Interacting Genes		20 interacting genes: ADAMTS4 ARF6 ASS1 BARD1 DHODH ECT2 EOLA1 HMGB1 JMJD1C LAMTOR5 MCPH1 PAXIP1 PRKD1 RCHY1 RIN3 SHBG SPINK7 STOM TNS2 USP25	40 interacting genes: ASB3 ASB8 BIN1 CD2AP CSRP3 CYP2C8 CYP46A1 DOK3 EPS8L2 EZH2 GATA1 GRAP2 ID2 KCTD17 LCK MPEG1 MT2A PLB1 POLR3F PSMD9 RAB5A RAB5B RAB5C RABAC1 RGS2 RTL8B SPATA12 SPRY4 SUV39H1 SYMPK TENT5A TGM1 TM4SF19 TNFAIP1 TSC1 TSSK3 ZBTB24 ZNF639 ZNF655 ZNF71
Entrez ID		4502	79890
HPRD ID		08863	11494
Ensembl ID		ENSG00000125148	ENSG00000100599
Uniprot IDs		P02795	Q6NSK7 Q6ZRC2 Q86U22 Q8TB24
PDB IDs		1MHU 2MHU	3U23 4WCI
Enriched GO Terms of Interacting Partners?
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