MST1R and EPOR

Number of citations of the paper that reports this interaction (PubMedID 14982882)
18

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		MST1R	EPOR
Description		macrophage stimulating 1 receptor	erythropoietin receptor
Image
GO Annotations	Cellular Component	Stress Fiber Vacuole Plasma Membrane Integral Component Of Plasma Membrane Basal Plasma Membrane Cell Surface Receptor Complex	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Nuclear Speck
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Activity Macrophage Colony-stimulating Factor Receptor Activity Protein Binding ATP Binding Enzyme Binding	Erythropoietin Receptor Activity Protein Binding Identical Protein Binding
	Biological Process	Phagocytosis Defense Response Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Single Fertilization Nervous System Development Positive Regulation Of Cell Population Proliferation Response To Virus Cell Migration Peptidyl-tyrosine Phosphorylation Positive Regulation Of Kinase Activity Macrophage Colony-stimulating Factor Signaling Pathway Positive Regulation Of MAP Kinase Activity Innate Immune Response Positive Regulation Of Protein Kinase B Signaling	Signal Transduction Brain Development Heart Development Erythropoietin-mediated Signaling Pathway Decidualization
Pathways		Signaling by MST1	Signaling by Erythropoietin Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phospholipase C gamma (PLCG) Erythropoietin activates STAT5 Erythropoietin activates RAS Erythropoietin activates RAS
Drugs		Fostamatinib	Darbepoetin alfa Erythropoietin Dibromotyrosine Peginesatide Methoxy polyethylene glycol-epoetin beta
Diseases
GWAS		Adult body size ( 32376654) Age at first birth ( 27798627) Body mass index ( 26426971 29273807) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Extremely high intelligence ( 29520040) Inflammatory bowel disease ( 23128233) Refractive error ( 32231278) Regular attendance at a gym or sports club ( 29970889) Regular attendance at a religious group ( 29970889) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 25082827) Walking pace ( 33128006)	Coronary artery disease ( 29212778) Serum erythropoietin levels ( 30271932)
Interacting Genes		25 interacting genes: AKT1 EPOR ERBB2 GAB1 GJB1 GPX1 GRB2 HYAL2 JAK2 MST1 PIK3R1 PLCG1 PPP1CA PTPRR RELA SFN SHC1 SRC STUB1 YES1 YWHAB YWHAE YWHAH YWHAQ YWHAZ	40 interacting genes: ATXN2L CBL CISH CRKL CSF2RB EGLN3 ELOB ELOC EPO GAB1 GAB2 GNAI1 GRAP GRB2 ICAM3 INPP5D IRS2 JAK2 KIT KITLG KLK3 LYN MAPK1 MAPK3 MST1R PIK3R1 PLCG1 PLCG2 PTPN11 PTPN6 RACK1 SH2B2 SHC1 SOCS2 SOCS3 STAT5A STAT5B SYK VAV1 VHL
Entrez ID		4486	2057
HPRD ID		02545	00587
Ensembl ID		ENSG00000164078	ENSG00000187266
Uniprot IDs		B4E058 G9JXB8 Q04912	P19235
PDB IDs		3PLS 4FWW 4QT8	1CN4 1EBA 1EBP 1EER 1ERN 2JIX 2MV6 4Y5V 4Y5X 4Y5Y 6E2Q 6MOE 6MOF 6MOH 6MOI 6MOJ 6MOK 6MOL
Enriched GO Terms of Interacting Partners?
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