MSN and NCF1

Number of citations of the paper that reports this interaction (PubMedID 11716484)
26

Data Source:
BioGRID (affinity chromatography technology, pull down)

		MSN	NCF1
Description		moesin	neutrophil cytosolic factor 1
Image
GO Annotations	Cellular Component	Uropod Extracellular Space Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Microvillus Focal Adhesion Cell Surface Basolateral Plasma Membrane Apical Plasma Membrane Filopodium Pseudopodium Microvillus Membrane Vesicle Apical Part Of Cell Perinuclear Region Of Cytoplasm Extracellular Exosome Cell Periphery Blood Microparticle	Cytoplasm Rough Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Membrane Extrinsic Component Of Membrane Dendrite Phagolysosome NADPH Oxidase Complex Neuronal Cell Body
	Molecular Function	Double-stranded RNA Binding Actin Binding Signaling Receptor Binding Structural Constituent Of Cytoskeleton Protein Binding Enzyme Binding Protein Kinase Binding Cell Adhesion Molecule Binding	Protein Binding Electron Transfer Activity Superoxide-generating NAD(P)H Oxidase Activity Superoxide-generating NADPH Oxidase Activator Activity SH3 Domain Binding Phosphatidylinositol Binding Phosphatidylinositol-3,4-bisphosphate Binding
	Biological Process	Immunological Synapse Formation Cytoskeleton Organization Leukocyte Cell-cell Adhesion Regulation Of Cell Shape Regulation Of Cell Size Positive Regulation Of Gene Expression Gland Morphogenesis Membrane To Membrane Docking T Cell Proliferation Establishment Of Epithelial Cell Apical/basal Polarity Leukocyte Migration Establishment Of Endothelial Barrier T Cell Aggregation Cellular Response To Testosterone Stimulus Positive Regulation Of Podosome Assembly T Cell Migration Regulation Of Organelle Assembly Positive Regulation Of Protein Localization To Early Endosome Positive Regulation Of Cellular Protein Catabolic Process Regulation Of Lymphocyte Migration Positive Regulation Of Early Endosome To Late Endosome Transport	Protein Targeting To Membrane Superoxide Metabolic Process Apoptotic Process Cellular Defense Response Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Electron Transport Chain Cellular Response To Reactive Oxygen Species Superoxide Anion Generation Innate Immune Response Respiratory Burst Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Positive Regulation Of Transcription, DNA-templated Positive Regulation Of JNK Cascade Regulation Of Respiratory Burst Involved In Inflammatory Response Cellular Response To Cadmium Ion Positive Regulation Of P38MAPK Cascade Reactive Oxygen Species Biosynthetic Process
Pathways		Recycling pathway of L1 Recycling pathway of L1 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea Signaling by ALK fusions and activated point mutants	ROS and RNS production in phagocytes Cross-presentation of particulate exogenous antigens (phagosomes) Detoxification of Reactive Oxygen Species VEGFA-VEGFR2 Pathway RHO GTPases Activate NADPH Oxidases RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle
Drugs			Dextromethorphan
Diseases
GWAS		Male-pattern baldness ( 28196072)	Systemic lupus erythematosus ( 33493351)
Interacting Genes		33 interacting genes: BCAP31 CD44 CD46 CD93 CDK11B CFC1 ERBB2 EZR ICAM1 ICAM2 ICAM3 L1CAM LINC01554 LMO2 MYBPC2 NCF1 NCF4 PLEC PPM1A PPM1B PRKAR2A PRKCQ ROCK1 SELL SELPLG SLC9A3R1 SMURF1 SPN TERF1 TRIM15 TSC1 VCAM1 VPS11	28 interacting genes: ACTB CSNK2B CYBA FASLG GAA GMNN KHDRBS1 MAPK9 MGAM MSN MYBPC1 MYBPC3 NCF2 NCF4 NOXA1 PKD1 PLA2G4A PRKCA PRKCB PRKCD PRKCZ PRKDC PTEN SH3RF1 SRSF2 SYTL1 TRAF4 TRIM9
Entrez ID		4478	653361
HPRD ID		02399
Ensembl ID		ENSG00000147065	ENSG00000158517
Uniprot IDs		P26038 V9HWC0	P14598
PDB IDs		1E5W 1EF1 1SGH 6TXQ 6TXS	1GD5 1K4U 1KQ6 1NG2 1O7K 1OV3 1UEC 1W70 1WLP
Enriched GO Terms of Interacting Partners?
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