ASPH and KCNIP4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		ASPH	KCNIP4
Description		aspartate beta-hydroxylase	potassium voltage-gated channel interacting protein 4
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Membrane Cortical Endoplasmic Reticulum Sarcoplasmic Reticulum Membrane	Cytoplasm Endoplasmic Reticulum Cytosol Plasma Membrane Voltage-gated Potassium Channel Complex
	Molecular Function	Structural Molecule Activity Calcium Ion Binding Protein Binding Structural Constituent Of Muscle Electron Transfer Activity Peptidyl-aspartic Acid 3-dioxygenase Activity	Voltage-gated Ion Channel Activity Potassium Channel Activity Calcium Ion Binding Protein Binding Potassium Channel Regulator Activity
	Biological Process	Muscle Contraction Electron Transport Chain Peptidyl-aspartic Acid Hydroxylation Positive Regulation Of Proteolysis Activation Of Cysteine-type Endopeptidase Activity	Potassium Ion Transmembrane Transport Protein Localization To Plasma Membrane Regulation Of Potassium Ion Transmembrane Transport
Pathways		Stimuli-sensing channels Ion homeostasis	Phase 1 - inactivation of fast Na+ channels
Drugs		Aspartic acid
Diseases
GWAS		Blood protein levels ( 30072576 29875488) BRCA1/2-negative high-risk breast cancer ( 30323354) Resting heart rate ( 28270201) Serum omega-6 to omega-3 polyunsaturated fatty acid ratio in metabolic syndrome ( 31991592) Urate levels in overweight individuals ( 25811787)	Cadmium levels ( 26025379) Colorectal cancer ( 29228715) Cough in response to angiotensin-converting enzyme inhibitor drugs ( 26169577) Diverticular disease ( 30177863) Lingual gyrus volume ( 31530798) Obesity-related traits ( 23251661) Parkinson disease and lewy body pathology ( 25663231) Post bronchodilator FEV1/FVC ratio ( 26634245) Postburn scar height ( 30595539) Rheumatoid arthritis ( 21156761) Suicidal ideation ( 20877300)
Interacting Genes		74 interacting genes: - AGR2 APP BGLAP CDSN CHRM5 CST1 CTSA CXorf66 DCD DEFB1 DHRSX ENPP6 FBXO7 FDCSP FGFBP1 FKBP7 GAL GAST GET3 GOLM1 GPR119 GPX7 GPX8 GSC2 GUCA2A IL21 INSL5 KCNIP1 KCNIP3 KCNIP4 LCN2 LRPAP1 LTA NUCB2 OCIAD1 OGT PCSK4 PDGFA PDGFRL PLAAT2 PLEKHF2 PRAP1 PRB1 PRB2 PRB4 PRH1 PTH PTN RAB2A RCN1 RELL2 RNASEH1 SCGB1C2 SDC2 SF3A2 SGTB SHISAL1 SLC51B SMIM11 SMIM19 SOD3 SPINK1 STAG1 TMEM167B TMX2 TNFRSF10B TRDN TUFM TXNDC15 UGT2B11 WFDC12 WFDC5 ZG16	11 interacting genes: APP ASPH COL1A2 GOLGA7 IL17A KCND2 LITAF MEOX2 PSEN1 PSEN2 TRH
Entrez ID		444	80333
HPRD ID		08996	12184
Ensembl ID		ENSG00000198363	ENSG00000185774
Uniprot IDs		B4DQ07 B7ZM96 Q12797	A8K4N3 Q6PIL6
PDB IDs		5APA 5JQY 5JTC 5JZ6 5JZ8 5JZA 5JZU 6Q9F 6Q9I 6QA5 6RK9
Enriched GO Terms of Interacting Partners?
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