MAP1LC3C and IRGM

Number of citations of the paper that reports this interaction (PubMedID 22174682)
95

Data Source:
BioGRID (two hybrid)

		MAP1LC3C	IRGM
Description		microtubule associated protein 1 light chain 3 gamma	immunity related GTPase M
Image			No pdb structure
GO Annotations	Cellular Component	Autophagosome Membrane Autophagosome Cytosol Microtubule Endomembrane System Organelle Membrane Cytoplasmic Vesicle Cytoplasmic Ribonucleoprotein Granule	Golgi Membrane Autophagosome Membrane Phagocytic Cup Mitochondrion Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Phagocytic Vesicle Membrane Cell Projection
	Molecular Function	Protein Binding Microtubule Binding Ubiquitin Protein Ligase Binding	GTPase Activity Protein Binding GTP Binding Protein Kinase Binding Protein Serine/threonine Kinase Activator Activity CARD Domain Binding BH3 Domain Binding
	Biological Process	Autophagosome Assembly Autophagy Of Mitochondrion Cellular Response To Nitrogen Starvation Cellular Response To Starvation Macroautophagy Protein Exit From Endoplasmic Reticulum Aggrephagy Autophagosome Maturation	Autophagosome Assembly Positive Regulation Of Protein Phosphorylation Defense Response Inflammatory Response Positive Regulation Of Autophagy Positive Regulation Of Peptidyl-threonine Phosphorylation Protein Destabilization Positive Regulation Of Peptidyl-serine Phosphorylation Cellular Response To Interferon-beta Defense Response To Bacterium Regulation Of Protein-containing Complex Assembly Innate Immune Response Protein Stabilization Defense Response To Gram-negative Bacterium Positive Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Protein Complex Stability Protein Lipidation Involved In Autophagosome Assembly CAMKK-AMPK Signaling Cascade Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Cellular Response To Lipopolysaccharide Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation By Symbiont Of Host Autophagy Cellular Response To Virus Positive Regulation Of Autophagosome Maturation
Pathways		Macroautophagy
Drugs
Diseases
GWAS		Hip circumference adjusted for BMI ( 28552196) Metabolite levels ( 23823483)	Cholangiocarcinoma in primary sclerosing cholangitis ( 28779025) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 18587394 28067908 17554261 17554300 21102463) Dimensional psychopathology (Arousal) ( 29496196) Inflammatory bowel disease ( 28067908 23128233)
Interacting Genes		32 interacting genes: AMBRA1 ANK2 ANK3 ATG13 ATXN3 CALCOCO2 CAPN3 CUL3 GMEB2 IRGM KBTBD6 KBTBD7 LAT LMNB1 MEFV MISP NEDD4 OPRM1 OPTN RHOXF1 RUFY4 STK3 TAX1BP1 TBC1D25 TNIP1 TP53INP1 TRIM21 TRIM32 TSR2 WDFY3 WDR81 ZNF24	5 interacting genes: ATG10 ATG5 MAP1LC3C NOD2 SH3GLB1
Entrez ID		440738	345611
HPRD ID		14226	19559
Ensembl ID		ENSG00000197769	ENSG00000237693
Uniprot IDs		Q9BXW4	A1A4Y4
PDB IDs		2NCN 3VVW 3WAM 3WAP 5DPW
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?