ALG11 and ARHGAP22

		ALG11	ARHGAP22
Description		ALG11 alpha-1,2-mannosyltransferase	Rho GTPase activating protein 22
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane	Nucleus Cytosol Focal Adhesion Glutamatergic Synapse
	Molecular Function	Alpha-1,2-mannosyltransferase Activity GDP-Man:Man3GlcNAc2-PP-Dol Alpha-1,2-mannosyltransferase Activity	GTPase Activator Activity Protein Binding
	Biological Process	Protein N-linked Glycosylation Oligosaccharide-lipid Intermediate Biosynthetic Process Mannosylation	Angiogenesis Signal Transduction Cell Differentiation Regulation Of Small GTPase Mediated Signal Transduction Activation Of GTPase Activity Regulation Of Postsynapse Organization
Pathways		Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG11 causes ALG11-CDG (CDG-1p)	RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle
Drugs
Diseases
GWAS			Conduct disorder ( 20585324) Daytime sleep phenotypes ( 27126917) Diabetic retinopathy ( 21310492) Macular thickness ( 30535121) Refractive error ( 32231278) Self-employment ( 23593239) Systolic blood pressure ( 31134134) Systolic blood pressure (education interaction) ( 31134134)
Interacting Genes		1 interacting genes: ARHGAP22	13 interacting genes: ALG11 CACNA1A CCNDBP1 CDC42 DEF6 FXR1 GPRIN2 IL1RAPL1 MAPK8 PTPN20 RAC1 RHOA ZNF488
Entrez ID		440138	58504
HPRD ID		11265	12476
Ensembl ID		ENSG00000253710	ENSG00000128805
Uniprot IDs		Q2TAA5	A0A2X0SFC0 Q7Z5H3
PDB IDs
Enriched GO Terms of Interacting Partners?
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