MNAT1 and HMGB1

Number of citations of the paper that reports this interaction (PubMedID 31694235)
4

Data Source:
BioGRID (two hybrid)

		MNAT1	HMGB1
Description		MNAT1 component of CDK activating kinase	high mobility group box 1
Image
GO Annotations	Cellular Component	Transcription Factor TFIIH Core Complex Nucleoplasm Transcription Factor TFIIH Holo Complex Cyclin-dependent Protein Kinase Activating Kinase Holoenzyme Complex CAK-ERCC2 Complex Transcription Factor TFIIK Complex	Condensed Chromosome Extracellular Region Extracellular Space Nucleus Nucleoplasm Early Endosome Endoplasmic Reticulum-Golgi Intermediate Compartment Cell Surface Transcription Repressor Complex Secretory Granule Lumen Alphav-beta3 Integrin-HMGB1 Complex Neuron Projection Ficolin-1-rich Granule Lumen
	Molecular Function	Protein Binding Zinc Ion Binding Protein N-terminus Binding Cyclin-dependent Protein Serine/threonine Kinase Activator Activity	Four-way Junction DNA Binding Bubble DNA Binding Transcription Cis-regulatory Region Binding Lipopolysaccharide Binding Phosphatidylserine Binding Damaged DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Transcription Coactivator Activity RNA Binding Double-stranded RNA Binding Single-stranded RNA Binding Cytokine Activity Integrin Binding Protein Binding Transcription Factor Binding DNA Binding, Bending Calcium-dependent Protein Kinase Regulator Activity Lyase Activity C-X-C Chemokine Binding Protein Kinase Activator Activity Chemoattractant Activity RAGE Receptor Binding DNA Polymerase Binding Supercoiled DNA Binding DNA-binding Transcription Factor Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle DNA Repair Nucleotide-excision Repair Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Adult Heart Development Ventricular System Development Negative Regulation Of Apoptotic Process Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Smooth Muscle Cell Proliferation Response To Calcium Ion Protein-containing Complex Assembly Negative Regulation Of DNA Helicase Activity	Negative Regulation Of Transcription By RNA Polymerase II Eye Development Myeloid Dendritic Cell Activation Endothelial Cell Proliferation Activation Of Innate Immune Response Plasmacytoid Dendritic Cell Activation Macrophage Activation Involved In Immune Response Dendritic Cell Chemotaxis Inflammatory Response To Antigenic Stimulus Regulation Of Tolerance Induction Regulation Of T Cell Mediated Immune Response To Tumor Cell DNA Topological Change Base-excision Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination Regulation Of Transcription By RNA Polymerase II Autophagy Inflammatory Response Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Autophagy Gene Silencing Negative Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Lung Development Neuron Projection Development Chromatin Assembly Regulation Of Restriction Endodeoxyribonuclease Activity Activation Of Protein Kinase Activity DNA Geometric Change Positive Regulation Of Mismatch Repair Negative Regulation Of Interferon-gamma Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production V(D)J Recombination Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Toll-like Receptor 9 Signaling Pathway T-helper 1 Cell Activation Endothelial Cell Chemotaxis Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of Apoptotic Process Apoptotic Cell Clearance Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of DNA Binding Positive Regulation Of MAPK Cascade Positive Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Blood Vessel Endothelial Cell Migration T-helper 1 Cell Differentiation Innate Immune Response Positive Regulation Of Myeloid Cell Differentiation Positive Regulation Of Glycogen Catabolic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Positive Chemotaxis Positive Regulation Of DNA Ligation Response To Glucocorticoid Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Positive Regulation Of Monocyte Chemotactic Protein-1 Production Positive Regulation Of Monocyte Chemotaxis Positive Regulation Of Wound Healing Neutrophil Clearance Cellular Response To Interleukin-7 Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Sprouting Angiogenesis Positive Regulation Of Vascular Endothelial Cell Proliferation Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Negative Regulation Of Apoptotic Cell Clearance Regulation Of Nucleotide-excision Repair Positive Regulation Of Dendritic Cell Differentiation
Pathways		Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Tat-mediated elongation of the HIV-1 transcript NoRC negatively regulates rRNA expression Formation of Incision Complex in GG-NER RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes Cyclin E associated events during G1/S transition Cyclin D associated events in G1 Cyclin A/B1/B2 associated events during G2/M transition Cyclin A:Cdk2-associated events at S phase entry mRNA Capping RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Transcription Termination RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE RUNX1 regulates transcription of genes involved in differentiation of HSCs	ER-Phagosome pathway Apoptosis induced DNA fragmentation MyD88:MAL(TIRAP) cascade initiated on plasma membrane TAK1 activates NFkB by phosphorylation and activation of IKKs complex MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) Pyroptosis Regulation of TLR by endogenous ligand Neutrophil degranulation Advanced glycosylation endproduct receptor signaling Advanced glycosylation endproduct receptor signaling TRAF6 mediated NF-kB activation
Drugs			Chloroquine Ethyl pyruvate
Diseases
GWAS		Exhaled carbon monoxide levels in smokers with chronic obstructive pulmonary disease ( 29631575) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502) Refractive error ( 32231278)	Adult body size ( 32376654) Apolipoprotein A1 levels ( 32203549) Blood osmolality (transformed sodium) ( 28360221) Carotid plaque burden ( 28282560) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Hippocampal volume ( 21116278) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Rapid response to perioperative phenylephrine (change in mean arterial pressure) ( 33168928) Red blood cell count ( 32888494) Triglyceride levels ( 32203549 32154731) Type 2 diabetes ( 30297969) Urate levels ( 31578528)
Interacting Genes		49 interacting genes: BEX3 BRCA1 CDK7 COPS6 DMAP1 E2F1 EEF1A1 ERCC2 ERCC3 ESR1 FOXP1 GOLGA2 GTF2E2 GTF2H1 GTF2H2 HMGB1 HPS6 LRIF1 MAGEC2 MAGEE2 MCM7 MDM4 MKRN3 MTA1 NKX3-1 POLR2A POU2F1 POU2F2 POU5F1 RB1 RBM48 RNF32 RNF41 RNF7 SUPT5H TET2 TP53 TRIM14 TRIM17 TRIM2 TRIM21 TRIM26 TRIM31 TRIM34 TRIM39 TRIM5 TRIM9 TRIML1 USP2	123 interacting genes: ACBD3 AGER AGTRAP ALK AR ATOH1 C1QBP C3 CASP3 CCAR1 CCNDBP1 CDK1 CEBPB CREBBP CRMP1 CSNK1A1 CTCF CTNNBL1 CUX1 DLAT DNAAF2 DNM2 DNMT1 DUX4 EIF1 ENAH EP300 ERF ERG28 FIP1L1 FLT1 FOS FOXA3 FOXC1 GOLM1 GTF2A1 HDLBP HES1 HMGA1 HNRNPK HNRNPU HOXA10 HOXB1 HOXB3 HOXC6 HOXD10 HOXD11 HOXD3 HOXD8 HOXD9 HPF1 HR HSPA5 IRF2 KRT7 LRIF1 MAP1B MAPKAPK5 MECP2 MIEN1 MNAT1 MNT MT2A NCAN NEUROD6 NEXN NFKB1 NR3C1 PCOLCE PGR PLAT PLG POU5F1 PPP2R3A PRKCA PRKDC PSEN1 PSMA7 PTPN2 PTPRZ1 RAD23B RAG1 RASAL2 RASSF4 RB1 RBPJ RELA RFX1 RPL29 RPS12 RPS20 RSF1 SIX5 SOX18 SPIN1 SPINT1 SRSF3 TAF1 TAF3 TBP TERF2 TERF2IP TFE3 TGIF1 TGM3 TLE1 TLE2 TLE5 TLR2 TLR4 TP53 TP73 UBC UBE2E3 UBE2I UBXN1 UHRF2 UNC119 WNK4 YY1 ZFP36 ZNF24 ZNF428
Entrez ID		4331	3146
HPRD ID		04042	01228
Ensembl ID		ENSG00000020426	ENSG00000189403
Uniprot IDs		A0A024R669 A0A024R688 P51948	A0A024RDR0 P09429
PDB IDs		1G25 6NMI 6O9L 6O9M 6TUN 6XBZ 6XD3 7B5O 7B5Q	2LY4 2RTU 2YRQ 6CG0 6CIJ 6CIK 6CIL 6CIM 6OEM 6OEN 6OEO
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?