MLLT3 and VAX1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		MLLT3	VAX1
Description		MLLT3 super elongation complex subunit	ventral anterior homeobox 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytosol Transcription Elongation Factor Complex Extracellular Exosome	Chromatin Nucleus
	Molecular Function	DNA Binding Chromatin Binding Protein Binding Histone Binding Lysine-acetylated Histone Binding Modification-dependent Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Intronic Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Chromatin DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Segment Specification Anterior/posterior Pattern Specification Gene Expression Positive Regulation Of Transcription, DNA-templated Hematopoietic Stem Cell Differentiation Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Chromatin Organization Regulation Of Stem Cell Division Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway	Negative Regulation Of Transcription By RNA Polymerase II Neuron Migration Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Neuroblast Proliferation Axon Guidance Central Nervous System Development Brain Development Neuron Differentiation Skeletal Muscle Cell Differentiation Camera-type Eye Development Roof Of Mouth Development
Pathways		Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS		Atrial fibrillation ( 29892015) Dietary fat liking ( 32516399) Estimated glomerular filtration rate ( 31152163) Hematocrit ( 32888494) Hemoglobin ( 32888494) Mean reticulocyte volume ( 32888494) Platelet distribution width ( 32888494) Response to montelukast in asthma (change in FEV1) ( 26083242) Systolic blood pressure ( 30578418)	Age at first birth ( 34211149) Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) Cleft lip with or without cleft palate ( 28054174) Nonsyndromic cleft lip ( 31609978) Nonsyndromic cleft lip with cleft palate ( 28232668) Nonsyndromic cleft lip with or without cleft palate ( 25775280) Orofacial clefts ( 20023658 28054174)
Interacting Genes		20 interacting genes: AFF1 ALKBH4 APP APPBP2 BCOR CBX8 CDK6 COL6A1 EEF1A1 FAM9A H3C1 LRIF1 LRRK2 MCM6 MIIP PTN RBM48 SGK1 VAX1 ZNF572	14 interacting genes: DVL3 EAF1 ESRRG HECW1 HMBOX1 MLLT3 PICK1 POLR3C PSMB1 RCOR3 RPRD1B SDCBP2 SPANXN2 USP20
Entrez ID		4300	11023
HPRD ID		01163	16052
Ensembl ID		ENSG00000171843	ENSG00000148704
Uniprot IDs		A0A0S2Z448 P42568	Q5SQQ9
PDB IDs		2LM0 2MV7 2N4Q 2NDF 2NDG 4TMP 5HJB 5HJD 5YYF 6B7G 6L5Z 6LS6 6MIL 6MIM
Enriched GO Terms of Interacting Partners?
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