MELTF and HPGDS

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		MELTF	HPGDS
Description		melanotransferrin	hematopoietic prostaglandin D synthase
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Early Endosome Endoplasmic Reticulum Lumen Plasma Membrane Cell Surface Anchored Component Of Plasma Membrane Recycling Endosome Extracellular Exosome	Nucleoplasm Cytoplasm Cytosol Intracellular Membrane-bounded Organelle
	Molecular Function	Iron Ion Binding Protein Binding	Magnesium Ion Binding Glutathione Transferase Activity Prostaglandin-D Synthase Activity Calcium Ion Binding Protein Binding Protein Homodimerization Activity
	Biological Process	Regulation Of Cell Growth Iron Ion Transport Positive Regulation Of Plasminogen Activation Regulation Of Cell Population Proliferation Iron Ion Homeostasis Positive Regulation Of Extracellular Matrix Disassembly Negative Regulation Of Substrate Adhesion-dependent Cell Spreading	Prostaglandin Biosynthetic Process Prostaglandin Metabolic Process Glutathione Metabolic Process Signal Transduction Locomotory Behavior
Pathways		Post-translational modification: synthesis of GPI-anchored proteins Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	Glutathione conjugation Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Drugs			Glutathione Tretinoin 2-(2f-Benzothiazolyl)-5-Styryl-3-(4f-Phthalhydrazidyl)Tetrazolium Chloride Glutathione disulfide 3-phenyl-5-(1H-pyrazol-3-yl)isoxazole PHENYL-5-(1H-PYRAZOL-3-YL)-1,3-THIAZOLE Tranilast 4-{[4-(4-fluoro-3-methylphenyl)-1,3-thiazol-2-yl]amino}-2-hydroxybenzoic acid 4-(BENZHYDRYLOXY)-1-[3-(1H-TETRAAZOL-5-YL)PROPYL]PIPERIDINE Nocodazole 3-(4-nitrophenyl)-1H-pyrazole 1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID
Diseases
GWAS		Malaria ( 31844061)	Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Blood protein levels ( 30072576 29875488) Testicular germ cell tumor ( 28604728 28604732 23666239)
Interacting Genes		11 interacting genes: CYSRT1 DERL1 DERL2 DERL3 EP300 HPGDS KRTAP1-1 KRTAP10-8 MESD NBPF19 NOTCH2NLA	7 interacting genes: ABHD17A ARRDC3 C14orf39 HK3 LIF MELTF PDE3B
Entrez ID		4241	27306
HPRD ID		01122	04001
Ensembl ID		ENSG00000163975	ENSG00000163106
Uniprot IDs		P08582 Q53XS6	A0A384P5J0 O60760
PDB IDs		6XR0	1IYH 1IYI 1V40 2CVD 2VCQ 2VCW 2VCX 2VCZ 2VD0 2VD1 3EE2 3KXO 3VI5 3VI7 4EC0 4EDY 4EDZ 4EE0 5AIS 5AIV 5AIX 5YWE 5YWX 5YX1 6N4E 6W58 6W8H
Enriched GO Terms of Interacting Partners?
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