MCM7 and INTS6

Number of citations of the paper that reports this interaction (PubMedID 17310990)
9

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		MCM7	INTS6
Description		minichromosome maintenance complex component 7	integrator complex subunit 6
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Nucleolus Cytosol Membrane MCM Complex CMG Complex	Nucleus Nucleoplasm Actin Cytoskeleton Integrator Complex
	Molecular Function	DNA Binding DNA Helicase Activity Single-stranded DNA Binding Protein Binding ATP Binding ATP Hydrolysis Activity Single-stranded DNA Helicase Activity	Transmembrane Signaling Receptor Activity Protein Binding
	Biological Process	Double-strand Break Repair Via Break-induced Replication DNA Replication DNA Unwinding Involved In DNA Replication DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication Cellular Response To DNA Damage Stimulus Cell Population Proliferation Response To Xenobiotic Stimulus Regulation Of Phosphorylation Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Xenobiotic Stimulus	SnRNA Processing SnRNA 3'-end Processing
Pathways		Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state	RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Refractive error ( 32231278) Subcortical volume (MOSTest) ( 32665545)	Amyotrophic lateral sclerosis (sporadic) ( 24529757)
Interacting Genes		78 interacting genes: ABI2 AK8 APP ASB8 C8orf34 CCDC102B CCND1 CCNH CDC42 CDC45 CDC6 CDC7 CDK7 CDKN1B CEP68 CHEK1 COG6 CRLS1 DBF4 DNAAF6 DUX4 DYNC1I1 ELOC ESCO2 FHL2 GOLGA2 H3-4 HIF1A IKBKG IKZF3 INTS6 KIFC3 LINC01554 LNX2 MAGEA6 MBIP MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM8 MCMBP MEOX2 MIPOL1 MNAT1 NAB2 NFKBIA ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 PLK1 PNMA1 RAD17 RB1 RBL1 RBL2 RBM8A RBPMS RINT1 RPA1 SMC1A SNTA1 SP2 SSX2IP TFIP11 TREX1 TRIM27 TRIM54 TRIM55 TRIM63 UBE3A UBQLN1 USHBP1	3 interacting genes: CTDP1 INTS3 MCM7
Entrez ID		4176	26512
HPRD ID		01154	05063
Ensembl ID		ENSG00000166508	ENSG00000102786
Uniprot IDs		A0A0S2Z4A5 C6EMX8 P33993	A0A024RDU0 B3KQH5 Q9UL03
PDB IDs		6XTX 6XTY	7CUN
Enriched GO Terms of Interacting Partners?
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